肿瘤预防与治疗2026，Vol.39Issue(6)：471-477,7.DOI:10.3969/j.issn.1674-0904.2026.06.006
不同分子分型乳腺癌的钼靶与动态对比增强磁共振成像影像特征分析及检出率比较
Mammography and Dynamic Contrast-Enhanced MRI:Imaging Features and Detection Rate Comparison across Breast Cancer Molecular Subtypes
邓丽佳 1张丹 2刘莉3
作者信息
- 1. 621000 四川 绵阳,绵阳市妇幼保健院·绵阳市儿童医院 放射影像科
- 2. 611535 成都,四川大学华西医院 乳腺外科
- 3. 621000 四川 绵阳,川北医学院附属三台医院 医学影像科
- 折叠
摘要
Abstract
Objective:To compare the differences in imaging features between mammography and dynamic contrast-en-hanced MRI(DCE-MRI)among different molecular subtypes of breast cancer,and to evaluate the detection rates of the two modalities when used alone or in combination for pathologically confirmed breast cancer.Methods:We retrospectively en-rolled 120 female patients with breast neoplasms confirmed by pathology who received mammography and DCE-MRI examina-tions from October 2019 to September 2024.Tumors were categorized according to immunohistochemical criteria into Luminal A,Luminal B(non-HER2-positive),HER2-positive(non-Luminal),and triple-negative breast cancer subtypes.The ima-ging features of mammography and DCE-MRI were compared across subtypes,and the detected case numbers and detection rates of the two modalities in each subtype were calculated.Results:Imaging features of mammography and DCE-MRI dif-fered across molecular subtypes.For Luminal A,Luminal B,and HER2-positive tumors,overall detection rates did not dif-fer among the three strategies(mammography,DCE-MRI,and the combination of the two)(P>0.05).For triple-negative tumors,overall detection rates differed significantly(P<0.05);pairwise comparisons using exact McNemar test with Bonferroni correction(α=0.017)showed that a statisti-cally significant difference existed only between mammography and the combined strategy(P<0.017).Conclusion:Mam-mography and DCE-MRI exhibit distinct imaging features across different molecular subtypes of breast cancer;combined ap-plication improves overall detection rates for pathologically confirmed breast cancer,with the greatest benefit observed in tri-ple-negative subtype.关键词
乳腺肿瘤/钼靶/动态对比增强磁共振/分子分型/检出率Key words
Breast neoplasms/Mammography/Dynamic contrast-enhanced MRI/Molecular subtype/Detection rate分类
医药卫生引用本文复制引用
邓丽佳,张丹,刘莉..不同分子分型乳腺癌的钼靶与动态对比增强磁共振成像影像特征分析及检出率比较[J].肿瘤预防与治疗,2026,39(6):471-477,7.
