上海交通大学学报（医学版）2026，Vol.46Issue(6)：795-800,6.DOI:10.3969/j.issn.1674-8115.2026.06.012
重性抑郁障碍相关睡眠表现及其潜在机制的研究进展
Research progress in sleep manifestations related to major depressive disorder and its potential mechanisms
摘要
Abstract
Major depressive disorder(MDD)is a common psychiatric disorder.It features high prevalence and high disability rates globally,imposing a heavy disease burden on society and families.Sleep problems are highly prevalent among patients with MDD,which are not only one of the core symptoms of MDD,but are also closely related to its onset,persistence,and recurrence,severely impairing patients'social functioning and quality of life.This article systematically reviews the common sleep problems in patients with MDD and the associated neurobiological mechanisms,and summarizes current clinical intervention strategies and their underlying mechanisms,aiming to provide scientific theoretical support for the clinical intervention of MDD and its comorbid sleep problems.关键词
重性抑郁障碍/睡眠特征/神经生物学机制/炎症因子Key words
major depressive disorder(MDD)/sleep characteristics/neurobiological mechanism/inflammatory factor分类
医药卫生引用本文复制引用
朱墨,陈俊..重性抑郁障碍相关睡眠表现及其潜在机制的研究进展[J].上海交通大学学报（医学版）,2026,46(6):795-800,6.基金项目
国家自然科学基金(82471554) （82471554）
上海市精神卫生中心"启航计划"人才项目(2022-QH-05). National Natural Science Foundation of China(82471554) （2022-QH-05）
Shanghai Mental Health Center"QI-Hang Plan"Talent Program(2022-QH-05). （2022-QH-05）
