上海交通大学学报（医学版）2026，Vol.46Issue(6)：801-809,9.DOI:10.3969/j.issn.1674-8115.2026.06.013
白细胞介素调控网络在炎症性肠病中的作用机制综述
Review of mechanism of interleukin regulatory network in inflammatory bowel disease
摘要
Abstract
Inflammatory bowel disease(IBD),which includes ulcerative colitis(UC)and Crohn's disease(CD),is a heterogeneous group of disorders characterized by chronic and recurrent gastrointestinal inflammation.The pathophysiological mechanisms of IBD are complex,involving numerous factors,including genetics,environmental exposure,dysbiosis of the gut microbiota,and abnormal immune responses,with the disruption of immune homeostasis being a central pathological component.Studies have shown that abnormal regulation of cytokine networks plays a key role in the onset and progression of IBD.Among these,interleukins(ILs),as a class of important signaling molecules,have attracted widespread attention in the pathogenesis and clinical treatment of IBD,and targeted therapies against ILs have demonstrated significant efficacy.This article systematically elucidates the association between ILs and IBD,provides an in-depth analysis of the mechanisms by which ILs function in the pathogenesis of IBD,and discusses the imbalance between pro-inflammatory ILs(such as IL-6,IL-17,and IL-23)and the anti-inflammatory IL-10,as well as the regulation of their corresponding signaling pathways.It also summarizes IL-targeted therapeutic strategies,including the clinical validation of biologics and novel therapies,with the aim of providing new tactics for the clinical management of IBD.关键词
白细胞介素/炎症性肠病/免疫调控/靶向治疗Key words
interleukin/inflammatory bowel disease/immune regulation/targeted therapy分类
医药卫生引用本文复制引用
李梦如,王海强..白细胞介素调控网络在炎症性肠病中的作用机制综述[J].上海交通大学学报（医学版）,2026,46(6):801-809,9.基金项目
国家自然科学基金培育支持计划项目(PYMS202501016) （PYMS202501016）
国家中医药管理局第五批全国中医临床优秀人才研修项目(国中医药人教函[2022]1号). National Natural Science Foundation of China Cultivation and Support Programme(PYMS202501016) （国中医药人教函[2022]1号）
Fifth Batch of the National Administration of Traditional Chinese Medicine's Training Programme for Outstanding Clinical TCM Talents(Guo Zhong Yi Yao Ren Jiao Han[2022]No.1). （Guo Zhong Yi Yao Ren Jiao Han[2022]No.1）
