山西中医药大学学报2026，Vol.27Issue(6)：672-677,6.DOI:10.19763/j.cnki.2096-7403.2026.06.25
炙甘草汤加味联合西药对症治疗对心肌梗死后心律失常患者氧化应激及炎症水平的影响
Effect of modified Zhigancao Decoction combined with symptomatic western medicine on oxidative stress and inflammatory levels in patients with post-myocardial infarction arrhythmias
摘要
Abstract
Objective:To observe the effect of modified Zhigancao Decoction combined with symptomatic western medicine on oxidative stress and inflammatory levels in patients with post-myocardial infarction arrhythmias.Methods:A to-tal of 106 patients with post-myocardial infarction arrhythmias admitted to the Department of Cardiac Function Examination of the First Affiliated Hospital of Henan University of Chinese Medicine from January 2024 to March 2025 were selected and divided into a symptomatic group(53 cases,receiving symptomatic treatment alone)and a decoction group(53 cases,receiv-ing modified Zhigancao Decoction plus symptomatic treatment).Both groups were treated continuously for 4 weeks.The two groups were compared in terms of electrocardiographic parameters,levels of CXC chemokine ligand 8(CXCL8),tumor ne-crosis factor-alpha(TNF-α),galectin-3(Gal-3),interleukin-6(IL-6),nuclear factor erythroid 2-related factor 2(NRF2),B-type brain natriuretic peptide(BNP),malondialdehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),as well as the incidence of adverse reactions.Results:There was no statistically significant difference in electro-cardiographic parameters between the two groups before treatment(P>0.05).After treatment,corrected QT interval(QTc),QRS duration,and QT dispersion(QTd)decreased in both groups compared with before treatment,and the electrocardio-graphic parameters in the decoction group were lower than those in the symptomatic group after treatment(P<0.05).Before treatment,there were no statistically significant differences in any of the observed indicators between the two groups(P>0.05).After treatment,the levels of CXCL8,Gal-3,MDA,TNF-α,IL-6,and BNP decreased in both groups compared with before treatment,while the levels of SOD,NRF2,and GSH-Px increased compared with before treatment.Moreover,after treatment,the above indicators in the decoction group were superior to those in the symptomatic group,with statistically sig-nificant differences(P<0.05,P<0.01).There was no statistically significant difference in the incidence of adverse reactions between the two groups(7.55%in the decoction group vs.11.32%in the symptomatic group)(P>0.05).Conclusion:Modi-fied Zhigancao Decoction combined with symptomatic western medicine can reduce oxidative stress,inhibit inflammation,and improve electrocardiographic parameters in patients with post-myocardial infarction arrhythmias.关键词
炙甘草汤/心肌梗死/心律失常/氧化应激/炎症因子/不良反应Key words
Zhigancao Decoction/myocardial infarction/arrhythmias/oxidative stress/inflammatory factors/ad-verse reactions分类
医药卫生引用本文复制引用
孙玉洁,谢世阳..炙甘草汤加味联合西药对症治疗对心肌梗死后心律失常患者氧化应激及炎症水平的影响[J].山西中医药大学学报,2026,27(6):672-677,6.基金项目
河南省中医药科学研究专项课题项目(2024ZY2033) （2024ZY2033）
