上海中医药杂志2026，Vol.60Issue(7)：10-16,7.DOI:10.16305/j.1007-1334.2026.z20251210005
基于"五神藏"理论探讨针刺治疗阿尔茨海默病的作用机制与临床研究进展
Mechanisms and clinical research progress of acupuncture in treating Alzheimer disease based on"five zang-organs storing spirits"theory
摘要
Abstract
Alzheimer Disease(AD)is a prevalent chronic,progressive,and degenerative neurological disorder in the elderly.It presents as a clinical syndrome characterized by cognitive and memory decline,impaired daily living activities,psychiatric symptoms,and behavioral disturbances resulting from organic brain lesions.From the perspective of traditional Chinese medicine(TCM),the core pathogenesis involves the depletion of essence and qi within the five zang-organs.Based on the"five zang-organs storing spirits"theory,the close relationship between AD and the five spirits—specifically,xinshen(heart-mind),ganhun(liver-ethereal soul),piyi(spleen-intellect),feipo(lung-corporeal soul),and shenzhi(kidney-will)—demonstrates that AD is not merely a localized brain disorder.As a cornerstone of TCM,acupuncture harmonizes the five zang-organs and improves the circulation of qi and blood.Recent clinical and experimental studies have shown that acupuncture targeting specific acupoints based on the"five zang-organs storing spirits"theory effectively enhances cognitive function,memory,and behavioral performance.Its underlying mechanisms involve multi-target actions,including the regulation of beta-amyloid(Aβ)deposition and Tau protein phosphorylation,inhibition of neuroinflammation,and modulation of the gut microbiota.Acupuncture protocols derived from this theory embody the holistic TCM concept of the"unity of form and spirit",offering novel insights into AD prevention and treatment.While showing significant clinical potential,the underlying mechanisms require further in-depth investigation.关键词
阿尔茨海默病/针刺/中医理论/临床疗效/作用机制Key words
Alzheimer disease/acupuncture/traditional Chinese medicine theory/clinical efficacy/mechanism of action引用本文复制引用
雒晶,袁海光,苏鑫,王国任,董昊..基于"五神藏"理论探讨针刺治疗阿尔茨海默病的作用机制与临床研究进展[J].上海中医药杂志,2026,60(7):10-16,7.基金项目
陕西省自然科学基础研究计划项目(2024JC-YBMS-YB-796) （2024JC-YBMS-YB-796）
陕西中医药大学研究生教育教学改革创新项目(JGCX202303) （JGCX202303）
