上海中医药杂志2026，Vol.60Issue(7)：92-100,9.DOI:10.16305/j.1007-1334.2026.z20250905006
芳香烃受体在特应性皮炎中的作用机制及中西医干预研究进展
Research progress on mechanisms of aryl hydrocarbon receptor in atopic dermatitis and integrated traditional Chinese and Western medicine intervention
摘要
Abstract
The aryl hydrocarbon receptor(AhR)is a ligand-dependent transcription factor that mediates environmental-cell interactions.It was previously recognized to be activated by environmental pollutants such as polycyclic aromatic hydrocarbons(PAHs)and participate in the metabolic activation of pollutants.Subsequent studies have revealed that AhR also mediates the development and progression of various skin diseases.In inflammatory skin conditions,activation of AhR can treat multiple inflammatory skin diseases.Both endogenous and exogenous ligands activate the AhR signaling pathway,thereby improving inflammatory conditions in patients with atopic dermatitis(AD).Traditional Chinese medicine(TCM)interventions also target this pathway to achieve therapeutic effects.Therefore,elucidating the mechanisms by which AhR ligands activate the AhR signaling pathway in AD and revealing the regulatory patterns of TCM on this pathway will provide novel insights for identifying next-generation therapeutic targets.关键词
芳香烃受体/特应性皮炎/炎症性皮肤病/中医药疗法/研究进展Key words
aryl hydrocarbons receptor/atopic dermatitis/inflammatory skin disease/traditional Chinese medicine therapy/research progress引用本文复制引用
陆冰萱,吴秀娟,姜淼,陈佛灵,曹溪芫,李继薇,汪晨冉,宋瑜..芳香烃受体在特应性皮炎中的作用机制及中西医干预研究进展[J].上海中医药杂志,2026,60(7):92-100,9.基金项目
上海市科委"科技创新行动计划"医学创新研究专项(20Y21901500,23Y31920304) （20Y21901500,23Y31920304）
上药-上中医联合研究院资助项目(E4-H2002103) （E4-H2002103）
