世界中医药2026，Vol.21Issue(5)：761-767,7.DOI:10.3969/j.issn.1673-7202.2026.05.001
通降颗粒中挥发油包合工艺研究
Volatile Oil Inclusion Technology of Tongjiang Granules
摘要
Abstract
Objective:To investigate the process conditions for β-cyclodextrin inclusion of volatile oil in Tongjiang Granules and to preliminarily characterize the inclusion complexes.Methods:The optimal inclusion process conditions for the volatile oil were de-termined using an orthogonal experimental design.The formation of new phases of the inclusion complexes was characterized using thin-layer chromatography(TLC),transmission electron microscopy(TEM),and ultraviolet-visible spectroscopy(UV-Vis).High-temperature stability was evaluated,and the optimal conformation between β-cyclodextrin and limonene was inferred using gas chro-matography(GC)and molecular docking.Results:The optimal inclusion conditions were determined to be a volatile oil(mL)to β-cyclodextrin(g)ratio of 1∶6,an inclusion temperature of 40 ℃,and a stirring time of 2 hours.After inclusion with β-cyclodextrin,the volatile oil formed a new phase.The thermal stability of the volatile oil was significantly improved.The β-cyclodextrin showed good affinity with limonene.Conclusion:This process enables the formation of stable inclusion complexes between volatile oil andβ-cyclodextrin,with a high inclusion efficiency and a simple procedure,demonstrating feasibility and rationality for practical pro-duction.关键词
通降颗粒/挥发油/β-环糊精/包合工艺/正交试验/分子对接/包合物/表征Key words
Tongjiang Granules/Volatile oil/Beta-cyclodextrin/Inclusion process/Orthogonal test/Molecular docking/Inclu-sion compounds/Characterization分类
医药卫生引用本文复制引用
熊登科,万玉荣,郑新,向阳,熊莉,李霞,李丽娟,黄志军..通降颗粒中挥发油包合工艺研究[J].世界中医药,2026,21(5):761-767,7.基金项目
国家工信部项目(TC2308068) （TC2308068）
湖北省重点研发计划项目(2025BCB050). （2025BCB050）
