世界中医药2026，Vol.21Issue(5)：789-794,6.DOI:10.3969/j.issn.1673-7202.2026.05.005
四君子汤对高压电烧伤大鼠免疫功能及血管内皮生长因子表达的影响
Effects of Sijunzi Decoction on Immune Function and Expression of Vascular Endothelial Growth Factor in High-voltage Electrical Burn Rats
摘要
Abstract
Objective:To investigate the effects of Sijunzi Decoction on immune function and vascular growth factors in rats with high-voltage electrical burns.Methods:A total of 120 healthy male SD rats were randomly assigned into four groups(n=30 each):sham injury group,model group,low-dose Sijunzi Decoction group,and high-dose Sijunzi Decoction group.Rats in the sham injury group did not receive electric shock,while a high-voltage electrical burn model was established in the other groups.After modeling,rats in the low-and high-dose groups received Sijunzi Decoction extract via gavage at 2.86 g/kg and 5.72 g/kg,respectively,while the sham injury and model groups received an equal volume of saline.Blood samples and immune organs were collected at 48 h,72 h,and 7 d after modeling.Serum immunoglobulins(IgG,IgA,IgM),inflammatory cytokines,vascular endothelial growth factor(VEGF),platelet-activating factor(PAF),and thrombopoietin(TPO)were measured using commercial kits.STAT3 mRNA and VEGF mRNA expression levels in serum were determined by reverse transcription quantitative PCR.Results:Compared with the sham injury group,the model group exhibited significantly decreased thymus and spleen indices and lower serum IgG,IgA,and IgM levels,along with significantly elevated serum pro-inflammatory cytokines,VEGF,PAF,and TPO levels(P＜0.05).Compared with the model group,rats in the low-and high-dose Sijunzi Decoction groups showed significant increases in thymus and spleen indices and serum IgG,IgA,IgM,and VEGF levels,and significant decreases in pro-inflammatory cytokines,PAF,and TPO levels(P＜0.05).Conclusion:Sijunzi Decoction may alleviate high-voltage electrical burn injury by upregulating STAT3 to enhance VEGF expression and promote healing,inhibiting PAF and TPO to reduce vascular injury,and improving immune function.关键词
四君子汤/高压电烧伤/免疫功能/血管内皮生长因子/血小板聚集/炎症反应/血小板活化因子/大鼠Key words
Sijunzi Decoction/High-voltage electrical burn/Immune function/Vascular endothelial growth factor/Platelet aggre-gation/Inflammatory response/Platelet-activating factor/Rat分类
医药卫生引用本文复制引用
邵洪波,崔源菲,高兵权,马嘉庆,吕芳,尹秋雨,邵明煜..四君子汤对高压电烧伤大鼠免疫功能及血管内皮生长因子表达的影响[J].世界中医药,2026,21(5):789-794,6.基金项目
国家自然科学基金面上项目(81871560) （81871560）
河北中医药科研计划项目(2022125). （2022125）
