世界中医药2026，Vol.21Issue(5)：921-931,11.DOI:10.3969/j.issn.1673-7202.2026.05.023
经典名方犀角地黄汤的历史沿革及处方考证
Historical Evolution and Textual Research on Classic Prescription Xijiao Dihuang Decoction
摘要
Abstract
Objective:To systematically investigate the historical evolution and key prescription information of Xijiao Dihuang De-coction using bibliometric methods,analyze its ancient and modern clinical applications,and provide guidance for clinical use.Methods:Ancient medical literature published before 1911 was retrieved from the 5th edition of Chinese Medical Canon,Duxiu Ac-ademic Search Database,Bolan Yishu,Traditional Chinese Medicine Think Tank,and other databases using"Xijiao Dihuang De-coction"as the keyword.Original ancient texts were consulted for verification and proofreading.Modern literature was retrieved from the China National Knowledge Infrastructure(CNKI),China Science Periodical Database(CSPD),and other databases using"Xi-jiao Dihuang Decoction"as the subject term.The search period ranged from January 1,1985 to April 30,2024,to obtain clinical re-search data on Xijiao Dihuang Decoction,followed by source verification and proofreading.The formula origin,historical evolution across dynasties,medicinal sources,dosage and processing methods,decoction and administration,as well as therapeutic effects and indications were systematically summarized and analyzed.Results:This formula originated from Shaoyao Dihuang Decoction in the Xiaopin Fang of the Northern and Southern Dynasties and was later collated by LIN Yi in the Northern Song Dynasty into the Impor-tant Prescriptions Worth a Thousand Gold for Emergency.Physicians of later generations generally inherited the original formula with further development.Based on textual research,the recommended medicinal materials and administration are as follows:con-centrated Bubali Cornu powder 138 g(as a substitute for rhinoceros horn),raw Rehmanniae Radix 110.4 g,raw Paeoniae Radix Rubra 41.4 g,and raw Moutan Cortex 27.6 g.The Chinese medicines are ground into coarse granules,decocted with 1 800 mL of water to a final volume of 600 mL per dose,and administered orally at 200 mL per dose,three times daily.The formula functions to cool the blood and resolve blood stasis,clear heat and expel pathogenic factors,nourish yin,and clear heat.It is mainly indicated for heat entering the blood aspect in typhoid fever and warm-disease conditions.Modern studies show that Xijiao Dihuang Decoction is commonly used in allergic purpura,psoriasis,thrombocytopenic purpura,systemic lupus erythematosus,and other diseases,whose pathogenesis is still classified as heat entering the blood aspect.Conclusion:A comprehensive bibliometric-based investigation of the historical evolution and key prescription information of Xijiao Dihuang Decoction provides a scientific basis for its standardized clinical application and pharmaceutical development.关键词
犀角地黄汤/经典名方/考证/关键信息/水牛角/犀角Key words
Xijiao Dihuang Decoction/Classical formula/Textual research/Key information/Bubali Cornu/Rhinoceros horn分类
医药卫生引用本文复制引用
曹佳蕾,任献青,梁绿圆,陈金雨,吕星航,张煜欣,李昱霖,于轶文,丁樱,魏炳琦..经典名方犀角地黄汤的历史沿革及处方考证[J].世界中医药,2026,21(5):921-931,11.基金项目
国家自然科学基金项目(82374519) （82374519）
河南省省级科技研发计划联合基金项目(222301420022) （222301420022）
河南省卫生健康委国家中医临床研究基地科研专项(2021JDZY013) （2021JDZY013）
2021年度河南省中原英才计划(育才系列)(豫组通[2021]44号). （育才系列）
