生命科学仪器2026，Vol.24Issue(3)：8-10,13,4.DOI:10.11967/2026240603
超声造影联合血管内皮生长因子、γ-谷氨酰转肽酶对原发性肝癌患者肝动脉化疗栓塞术后疗效评价的价值研究
Value of Contrast-enhanced Ultrasound Combined with Vascular Endothelial Growth Factor And γ-glutamyl Transpeptidase in Evaluating The Curative Effect of Patients with Primary Liver Cancer after Transcatheter Arterial Chemoembolization
摘要
Abstract
Objective:To analyze the value of contrast-enhanced ultrasound(CEUS)combined with vascular endo-thelial growth factor(VEGF)and γ-glutamyltranspeptidase(GGT)in evaluating the curative effect after tran-scatheter arterial chemoembolization(TACE)in patients with primary liver cancer(HCC).Methods:100 patients with HCC who were diagnosed and treated in Zhanjiang Central People's Hospital from July 2024 to June 2025 were selected.All patients underwent CEUS examination one week before operation and one month and three months af-ter operation,and their serum VEGF and GGT levels were detected at the same time.Three months after opera-tion,their clinical efficacy was evaluated according to the evaluation criteria of solid tumor efficacy,and they were divided into effective group(complete remission+partial remission,n=64)and ineffective group(stable disease)CEUS-related parameters,serum VEGF and GGT levels were compared between the two groups at different time points before and after operation,and the correlation between each index and clinical efficacy was analyzed,as well as the diagnostic efficiency of joint detection for TACE.Results:One month and three months after operation,the score of blood perfusion intensity in the effective group was lower than that in the ineffective group,and the lesion reduction rate was higher than that in the ineffective group(P<0.05).One month and three months after opera-tion,the levels of serum VEGF and GGT in the effective group were lower than those in the ineffective group(P<0.05).Correlation analysis showed that 3 months after operation,CEUS blood perfusion intensity,serum VEGF and GGT levels were negatively correlated with the lesion reduction rate(r=-0.682,-0.715,-0.653,P<0.05).The sensitivity、specificity and accuracy of CEUS combined with VEGF and GGT in evaluating the efficacy of TACE were higher than those of single index(P<0.05).Conclusion:CEUS combined with serum VEGF and GGT can comprehensively reflect the changes of tumor blood supply,angiogenesis and liver function in HCC pa-tients after TACE,which is helpful to adjust the treatment plan of patients in time.关键词
原发性肝癌/超声造影/血管内皮生长因子/γ-谷氨酰转肽酶Key words
Primary liver cancer/Contrast enhanced ultrasound/Vascular endothelial growth factor/γ-glutamyl transpeptidase分类
医药卫生引用本文复制引用
许杨明,谭显良,陈淑娴..超声造影联合血管内皮生长因子、γ-谷氨酰转肽酶对原发性肝癌患者肝动脉化疗栓塞术后疗效评价的价值研究[J].生命科学仪器,2026,24(3):8-10,13,4.基金项目
2024年湛江市非资助科技攻关计划项目编号:2024B01179 （）
