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Enrichment and amplification of secreted α-synuclein from cellular model and saliva of patients with synucleinopathies

Wuxian Xu Mingyue Luan Zhaoxia Wang Jianwen Deng Li Zhu

生物物理学报（英文）2026，Vol.12Issue(3)：137-150,14.

生物物理学报（英文）2026，Vol.12Issue(3)：137-150,14.DOI:10.52601/bpr.2025.250014

Enrichment and amplification of secreted α-synuclein from cellular model and saliva of patients with synucleinopathies

Wuxian Xu ¹Mingyue Luan ²Zhaoxia Wang ²Jianwen Deng ²Li Zhu³

作者信息

1. Sino-Danish College,University of Chinese Academy of Sciences,Beijing 100049,China||State Key Laboratory of Cognitive Science and Mental Health,Institute of Biophysics,Chinese Academy of Sci-ences,Beijing 100101,China
2. Department of Neurology,Peking University First Hospital,Beijing 100034,China
3. Sino-Danish College,University of Chinese Academy of Sciences,Beijing 100049,China||State Key Laboratory of Cognitive Science and Mental Health,Institute of Biophysics,Chinese Academy of Sci-ences,Beijing 100101,China||College of Life Sciences,University of Chinese Academy of Sciences,Beijing 100049,China
折叠

摘要

关键词

α-Synuclein/Parkinson's disease/Seeding activity/RT-QuIC/Saliva biomarkers/Synucleinopathies

Key words

α-Synuclein/Parkinson's disease/Seeding activity/RT-QuIC/Saliva biomarkers/Synucleinopathies

引用本文复制引用

Wuxian Xu,Mingyue Luan,Zhaoxia Wang,Jianwen Deng,Li Zhu..Enrichment and amplification of secreted α-synuclein from cellular model and saliva of patients with synucleinopathies[J].生物物理学报（英文）,2026,12(3):137-150,14.

基金项目

This work was supported by the National Natural Science Foundation of China(32271200),the Capitals Funds for Health Improvement and Research(2022-4-40716),and the National Key Research and Development Program of China(2019YFA0508603).We are indebted to the cooperation of the patients and their families.Figures are created at https://BioRender.com. （32271200）

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