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Structural basis for the ion selectivity of potassium-chloride cotransporter KCC4 revealed by cryo-EM titration

Yuan Xie Binming Han Xin Tao Fangjun Song Cheng Zhao Eric Delpire Jingyuan Li Shan Wu Jiangtao Guo

生物物理学报（英文）2026，Vol.12Issue(3)：193-206,14.

生物物理学报（英文）2026，Vol.12Issue(3)：193-206,14.DOI:10.52601/bpr.2025.240057

Structural basis for the ion selectivity of potassium-chloride cotransporter KCC4 revealed by cryo-EM titration

Yuan Xie ¹Binming Han ²Xin Tao ³Fangjun Song ⁴Cheng Zhao ⁴Eric Delpire ⁵Jingyuan Li ²Shan Wu ³Jiangtao Guo⁶

作者信息

1. Department of Neurosurgery,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China
2. School of Physics,Zhejiang University,Hangzhou 310058,China
3. State Key Laboratory of Biocatalysis and Enzyme Engineering,Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources,Hubei Key Laboratory of Industrial Biotechnology,School of Life Sciences,Hubei University,Wuhan 430062,China
4. Department of Biophysics and Department of Neurology of the Fourth Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China
5. Department of Anesthesiology,Vanderbilt University School of Medicine,Nashville,TN 37232,USA
6. Department of Biophysics and Department of Neurology of the Fourth Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China||Nanhu Brain-Computer Interface Institute,Hangzhou 311100,China||NHC and CAMS Key Laboratory of Medical Neurobiology,MOE Frontier Science Center for Brain Science and Brain-machine Integration,School of Brain Science and Brain Medicine,Zhejiang University,Hangzhou 310058,China||State Key Laboratory of Plant Environmental Resilience,College of Life Sciences,Zhejiang University,Hangzhou 310058,China||Cancer Center,Zhejiang University,Hangzhou 310058,China
折叠

摘要

关键词

KCC4/Cryo-EM titration/Ions selectivity/Molecular dynamic simulation/Ions cotransport

Key words

KCC4/Cryo-EM titration/Ions selectivity/Molecular dynamic simulation/Ions cotransport

引用本文复制引用

Yuan Xie,Binming Han,Xin Tao,Fangjun Song,Cheng Zhao,Eric Delpire,Jingyuan Li,Shan Wu,Jiangtao Guo..Structural basis for the ion selectivity of potassium-chloride cotransporter KCC4 revealed by cryo-EM titration[J].生物物理学报（英文）,2026,12(3):193-206,14.

基金项目

Single particle cryo-EM data were collected at the Cryo-Electron Microscopy Facility of Hubei University and the Center of Cryo-Electron Microscopy at Zhejiang University.This work was supported in part by the National Natural Science Foundation of China(32200803 to Y.X.,32371204 to J.G.,32471319 to S.W.,and 11722434 and 11874319 to J.L.),the Ministry of Science and Technology(2020YFA0908501 to J.G.),and the Fundamental Research Funds for the Central Universities(2021FZZX001-28 and 2025ZFJH01-01 to J.G.).J.G.is supported MOE Frontier Science Center for Brain Science&Brain-Machine Integration,Zhejiang University.J.G.gratefully acknowledges the support of K.C.Wong Education Foundation.Y.X.is granted by the A-level Doctoral Research Foundation from Xijing Hospital,Fourth Military Medical University(XJARC05)and by Special Project of A-level Doctoral Talent Support Program from Xijing Hospital,Fourth Military Medical University(AL202406).S.W.is supported by the Distinguished Young Scholars of Hubei Province(2022CFA078),the Knowledge Innovation Program of the Wuhan-Shugung Project(2023020201020418),and the National Key Research and Development Program of China(2020YFA0908400). （32200803 to Y.X.,32371204 to J.G.,32471319 to S.W.,and 11722434 and 11874319 to J.L.）

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