实用妇产科杂志2026，Vol.42Issue(6)：492-496,5.
血清sE-cadherin和AGR2水平与ⅠA1～ⅡA2期子宫颈癌患者根治术后复发的相关性
The Correlation between Serum Levels of Soluble E-cadherin and Anterior Gra-dient Protein2(AGR2)and Postoperative Recurrence in Patients with Stage ⅠA1-ⅡA2 Cervical Cancer Undergoing Radical Surgery
摘要
Abstract
Objective:To investigate the correlation between serum soluble E-cadherin(sE-cadherin),anterior gradient protein 2(AGR2),and postoperative recurrence in patients with stage ⅠA1-ⅡA2 cervical cancer who received radical surgery.Method:The clinical data of 133 patients with stage ⅠA1-ⅡA2 cervical cancer who un-derwent laparoscopic radical hysterectomy at the First Affiliated Hospital of Xinjiang Medical University from Janu-ary 2021 to June 2023 were retrospective analyzed.According to tumor recurrence during the 2-year postoperative follow-up,the patients were divided into the recurrence group(n=28)and the non-recurrence group(n=105).General clinical data and preoperative laboratory indicators were compared between the two groups.The influen-cing factors of postoperative recurrence in patients with stage ⅠA1 to ⅡA2 cervical cancer were analyzed by Cox regression analysis.The dose-response relationship and predictive efficacy of serum sE-cadherin and AGR2 lev-els and recurrence after radical resection in patients with stage ⅠA1 to ⅡA2 cervical cancer after radical surgery were analyzed by restricted cubic spline method(RCS)and receiver operating characteristic(ROC)curve.Results:The proportion of lymph node metastasis,vascular tumor thrombus,and serum levels of CYFRA21-1,sE-cadherin,and AGR2 in the recurrent group were higher than those in the non recurrent group,with statistically significant differences(P<0.05).Cox regression analysis showed that lymph node metastasis,vascular tumor thrombus,serum sE-cadherin,and AGR2 were influencing factors for postoperative recurrence in patients with stage ⅠA1-ⅡA2 cervical cancer after radical surgery(P<0.05).RCS analysis revealed a non-linear dose-re-sponse relationship between serum levels of sE-cadherin and AGR2 and postoperative recurrence in patients with stage ⅠA1-ⅡA2 cervical cancer after radical surgery(P<0.05).ROC curve analysis showed that serum sE-cadherin and AGR2,both individually and in combination,had a certain predictive power for postoperative re-currence in patients with stage ⅠA1-ⅡA2 cervical cancer after radical surgery,and the combined predictive power was higher.Conclusions:Serum levels of sE-cadherin and AGR2 are associated with postoperative recur-rence in patients with stage ⅠA1-ⅡA2 cervical cancer after radical surgery.The two indicators can assist in ear-ly clinical prediction of postoperative recurrence risk.关键词
子宫颈癌/根治术/复发/可溶性E-钙黏蛋白/前梯度蛋白2/相关性Key words
Cervical cancer/Radical surgery/Recurrence/Soluble E-cadherin/Anterior gradient protein 2/Correlation分类
医药卫生引用本文复制引用
李燕,德丽娜尔·乌尔肯别克..血清sE-cadherin和AGR2水平与ⅠA1～ⅡA2期子宫颈癌患者根治术后复发的相关性[J].实用妇产科杂志,2026,42(6):492-496,5.基金项目
新疆维吾尔自治区"天山英才"培养计划医药卫生高层次人才项目(编号:TSYC202401B042) （编号:TSYC202401B042）
