时珍国医国药2026，Vol.37Issue(12)：2257-2262,6.DOI:10.70976/j.1008-0805.SZGYGY-2026-1208
基于标准汤剂的吴茱萸配方颗粒制备工艺研究
Study on preparation technology of Fructus Euodiae Formula Granule(吴茱萸配方)based on standard decoction
摘要
Abstract
Objective To study the preparation technology of Fructus Euodiae Formula Granule(吴茱萸配方,FEFG)based on its standard decoction.Methods After preparing Fructus Euodiae(FE)standard decoction,using extraction rate,transfer rates of limonin,evodiamine,and rutaecarpine as evaluation indicators,and taking water volume,extraction time,and extraction cycles as influencing factors,orthogonal experiments were conducted to optimize the extraction process and investigate concentration temperature,drying method,and excipient ratio to refine the formula granule preparation.Results The optimal extraction process involves using 8 times the amount of water for two extractions,each lasting 1.5 h.The optimal concentration process is vacuum concentration at 70℃ or below for no more than 9 h.The optimal drying process requires a concentrated liquid density of 1.03-1.05 g/cm³ followed by spray drying.With the addition of 0％-7％ excipients,dry granulation is performed.Both the extract yield and content of various components are essentially consistent with those of the standard decoction.Conclusion This study optimized the production process of FEFG using standard decoc-tion as the quality benchmark,thereby ensuring the quality consistency between the formula granules and traditional FE decoction.The optimized process guarantees the safety,efficacy,stability,and controllability of clinical medication,while providing novel technical approaches for the preparation of FE and other Chinese herbal formula granules.关键词
吴茱萸/标准汤剂/配方颗粒/工艺研究Key words
Fructus Euodiae(吴茱萸)/Standard decoction/Formula granules/Technology research分类
医药卫生引用本文复制引用
张伟娜,闫晓鑫,田聪慧,张志强,杜守颖..基于标准汤剂的吴茱萸配方颗粒制备工艺研究[J].时珍国医国药,2026,37(12):2257-2262,6.基金项目
国家中医药管理局高水平重点学科建设项目-中药药剂学学科(zyyzdxk-2023272) （zyyzdxk-2023272）
