时珍国医国药2026，Vol.37Issue(13)：2478-2483,6.DOI:10.70976/j.1008-0805.SZGYGY-2026-1311
基于熵权法联合灰色关联度法的贯众药材与饮片的质量评价
Evaluation of the quality of Rhizoma Dryopteridis herbal materials and decoction pieces based on entropy weight method combined with grey relation analysis
摘要
Abstract
Objective To evaluate the quality of Rhizoma Dryopteridis herbal materials and decoction pieces using a combination of entropy weight(EW)and grey relation analysis(GRA).Methods 15 batches of Rhizoma Dryopteridis herbal materials and 9 batches of decoction pieces were selected.According to the general chapters of the Chinese Pharmacopoeia(中国药典)2020 Volume Ⅳ,10 indi-cators were measured for Rhizoma Dryopteridis herbal materials and decoction pieces,including moisture,total ash,acid-insoluble ash,extract,sulfur dioxide residue,heavy metals and harmful elements(including lead,cadmium,arsenic,mercury,and copper).The EW method was employed to determine the weights of each indicator,while GRA was applied to evaluate the quality of the herbal materials and decoction pieces.Results The content of the 10 indicators in the 15 batches of herbal materials and 9 batches of decoction pieces was almost consistent;the EW analysis showed that the moisture was generally lower than the other indicators among the low-quality indicators;copper had the highest information entropy and the lowest weight,at 0.9865 and 0.0469,respectively;moisture had the lowest information entropy and the highest weight,at 0.9349 and 0.2262,respectively;GRA showed that the correlation degrees of all evaluation indicators for the 15 batches of Rhizoma Dryopteridis herbal materials and 9 batches of decoction pieces relative to the opti-mal and worst reference sequences were relatively consistent,with moisture showing a close correlation.Additionally,combining EW with GRA,it was found that the relative correlation between the herbal medicine and the decoction pieces ranged from 0.3575 to 0.6431.The highest quality was the decoction piece batch Y5,and the lowest quality was the herbal medicine batch S2,indicating that there were significant quality differences among the 24 batches of samples collected;Finally,a comparison of the quality grades of the samples revealed that all were at Grade Ⅲ or above,with 19 batches at Grade I,3 batches at Grade Ⅱ,and 2 batches at Grade Ⅲ.All 9 batches of decoction pieces were classified as Grade I,while among the 15 batches of herbal materials,10 were Grade I,3 were Grade II,and 2 were Grade Ⅲ.Overall,the quality of the decoction pieces was superior to that of the herbal materials.Conclusion The EW and GRA models constructed based on multiple indicator components were used to evaluate the quality of different batches of Rhizoma Dryopteridis herbal materials and decoction pieces collected in this study.The method is simple and objective,providing a reference for quality control of Rhizoma Dryopteridis herbal materials and decoction pieces.关键词
贯众/熵权法/灰色关联度/质量评价Key words
Rhizoma Dryopteridis/Entropy weight method/Grey relation analysis/Quality evaluation分类
医药卫生引用本文复制引用
雍峰,蔺瑞丽,张明童,谢楠,马潇,杨明俊..基于熵权法联合灰色关联度法的贯众药材与饮片的质量评价[J].时珍国医国药,2026,37(13):2478-2483,6.基金项目
甘肃省药品监督管理局青年科技创新项目(2024GSMPA010) （2024GSMPA010）
甘肃省药品监督管理局中药材及饮片质量控制重点实验室开放基金项目(2025GSMPA-KL06) （2025GSMPA-KL06）
