天津中医药大学学报2026，Vol.45Issue(6)：734-745,12.DOI:10.11656/j.issn.1673-9043.2026.06.14
炎症-血管新生串扰作为糖尿病大动脉血管病变的新靶点:临床证据、机制发现及中医药防治潜力
Inflammation-angiogenesis crosstalk as a novel target for diabetic macrovascular complications:Clinical evidence,mechanism insights,and the potential of traditonal Chinese medicine in prevention and treatment
摘要
Abstract
Diabetic macrovascular complications are characterized by atherosclerosisas a core feature.Hyperglycemia leads to endothelial dysfunction,imbalanced angiogenesis,and plaque instability through mechanisms such as oxidative stress,accumulation of advanced glycosylation end products,and chronic inflammation,thereby contributing to coronary artery disease,cerebrovascular disease,and peripheral arterial disease.The complex pathophysiological progression and underlying pathogenic mechanisms of these complications have hindered significant breakthroughs in new drug development.Recent studies suggest that inflammation-angiogenesis crosstalk(IAC)may serve as a"common soil"for diabetic vascular complications,and targeting IAC holds promise for overcoming current therapeutic limitations.This article systematically reviews the pathogenesis of diabetic macrovascular complications and explored the role and clinical significance of IAC.Traditional Chinese Medicine(TCM)exhibits unique advantages in this field by leveraging multi-target regulation to simultaneously suppress inflammation and promote functional angiogenesis.This review provides an in-depth analysis of the inflammation-angiogenesis crosstalk mechanism and the multi-pathway intervention strategies of TCM,offering novel insights into the prevention and treatment of diabetic macrovascular complications.Future research should further validate the regulatory of key targets and promote the clinical translation of integrated traditional Chinese and Western medicine approaches.关键词
糖尿病大动脉血管病变/炎症-血管新生串扰/中药复方/中药单体Key words
diabetic macrovascular complications/inflammation-angiogenesis crosstalk/traditional Chinese medicine compound prescriptions/monomeric components of traditional Chinese medicine分类
医药卫生引用本文复制引用
李思雨,范斯文,张君怡,朱彦,贺爽..炎症-血管新生串扰作为糖尿病大动脉血管病变的新靶点:临床证据、机制发现及中医药防治潜力[J].天津中医药大学学报,2026,45(6):734-745,12.基金项目
国家自然科学基金资助项目(82304756,82474109). （82304756,82474109）
