天津中医药大学学报2026，Vol.45Issue(6)：746-752,7.DOI:10.11656/j.issn.1673-9043.2026.06.15
益肾养肝合剂有效成分抗骨质疏松的机制研究进展
Research progress on the mechanisms of the active ingredients in Kidney-and Liver-Nourishing Compound against osteoporosis
摘要
Abstract
Osteoporosis(OP)is a common bone metabolic disease.The key pathological mechanism of OP is the imbalance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption,which involves a series of complex and highly regulated cytokines and signaling pathways.Calcitonin and bisphosphonates are mainly used to treat OP based on the regulatory mechanisms of skeletal homeostasis;however,long-term use of certain medications can lead to increased drug resistance and even serious adverse reactions.Kidney-and Liver-Nourishing Compound exerts the effects of invigorating qi and strengthening the spleen,tonifying the kidney and nourishing the liver,and reinforcing muscles and bones.Clinically,it is often used to treat OP resulting from various etiologies.This paper systematically reviews the mechanisms by which the active components of the kidney-and liver-nourishing compound exert therapeutic effects on OP,aiming to provide ideas and approaches for the development of anti-osteoporosis drugs.关键词
骨质疏松症/骨代谢/作用机制/益肾养肝合剂Key words
osteoporosis/bone metabolism/mechanism of action/kidney-and liver-nourishing Compound分类
医药卫生引用本文复制引用
曹秀楠,欧阳慧子,陈路,陈涛,范栢爽,高英杰,柴士伟..益肾养肝合剂有效成分抗骨质疏松的机制研究进展[J].天津中医药大学学报,2026,45(6):746-752,7.基金项目
天津市南开区中医药传承创新发展示范试点项目(20240204004) （20240204004）
中国医药卫生事业发展基金会资助课题项目. （）
