天津中医药大学学报2026，Vol.45Issue(6)：753-761,9.DOI:10.11656/j.issn.1673-9043.2026.06.16
透明质酸功能化的纳米递送系统改善中药活性成分口服生物利用度的研究进展
Advances in hyaluronic acid-functionalized nano-delivery system for improving oral bioavailability of active ingredients in traditional Chinese medicine
摘要
Abstract
For the delivery of traditional Chinese medicine(TCM)active ingredients that are poorly soluble,easily metabolized,and difficult to cross biological barriers,hyaluronic acid-functionalized nanocarrier systems demonstrate multiple advantages,primarily due to their excellent biocompatibility and biodegradability.These carriers effectively enhance the solubility of TCM active ingredients,maintain drug stability,and promote intestinal absorption,thereby significantly improving the bioavailability of oral administration.This review summarizes the current published research findings on hyaluronic acid-functionalized nanocarrier systems as oral drug delivery carriers for delivering active components of TCM.The aim is to provide new strategies for improving the oral bioavailability of active components of TCM and to offer new avenues for advancing the modernization of TCM.关键词
中药活性成分/透明质酸及其衍生物/口服生物利用度/药物递送系统Key words
active ingredients of traditional Chinese medicine/hyaluronic acid and its derivatives/oral bioavailability/drug delivery system分类
医药卫生引用本文复制引用
张韫馨,智慧,孙玉姣,李英鹏..透明质酸功能化的纳米递送系统改善中药活性成分口服生物利用度的研究进展[J].天津中医药大学学报,2026,45(6):753-761,9.基金项目
国家自然科学基金面上项目(82074030). （82074030）
