塔里木大学学报2026，Vol.38Issue(3)：68-76,9.DOI:10.3969∕j.issn.1009-0568.2026.03.007
副结核病疫苗研究进展
Mycobacterium avium subspecies paratuberculosis vaccine:a review
摘要
Abstract
Paratuberculosis is a significant infectious disease in animals caused by Mycobacterium avium subspecies paratuberculosis(MAP)and characterized by chronic granulomatous enteritis.This disease extensively affects cattle,sheep,and various other animals.Annually,the disease inflicts billions of US dollars in economic damage on the global livestock industry worldwide.Furthermore,the potential correlation between MAP and Crohn's disease in humans has garnered considerable interest within the public health domain.Currently,commercial paratuberculosis vaccines face several commonly have limitations,including inadequate immune-protection,interference with bovine tuberculosis diagnosis,and injection site lesions,which hinder their ability to meet the prevention and control requirements of modern large-scale livestock production.This review systematically outlines the research progress and current status of paratuberculosis vaccines,and thoroughly analyzes the immunogenicity and limitations of vaccines including whole-cell vaccines,attenuated live vaccines,subunit vaccines,and peptide vaccines.Taking into account the geographical variability of globally prevalent strains,this review proposes a future vaccine strategy of prioritizing indigenous strains,synergizing multiple antigens,and achieving diagnostic compatibility,aiming to provide a theoretical basis for the optimization,upgrading,and clinical translation of paratuberculosis vaccines,and to promote the scientific prevention,control,and effective management of animal paratuberculosis.关键词
副结核疫苗/鸟分枝杆菌副结核亚种(MAP)/疫苗类型/免疫保护/诊断干扰/本土菌株/多抗原协同Key words
paratuberculosis vaccines/Mycobacterium avium subspecies paratuberculosis/types of vaccines/immune-protection/diagnostic interference/local strains/multi-antigen synergy分类
农业科技引用本文复制引用
丁剑,米晓云,魏婕,苗书魁,党娜娜,郭厚均,石依,魏玉荣..副结核病疫苗研究进展[J].塔里木大学学报,2026,38(3):68-76,9.基金项目
国家自然科学基金地区科学基金项目(32260886) （32260886）
