武警医学2026，Vol.37Issue(6)：477-483,7.DOI:10.3969/j.issn.1004-3594.2026.06.004
老年人腰臂比与代谢功能障碍相关脂肪性肝病及肝纤维化的相关性研究
Study on the association between the waist-to-arm ratio and both metabolic dysfunction-associated steatotic liver disease and hepatic fibrosis in older adults
陈昭光 1于剑锋 1王燕斌 1张冬磊 1郝建宇 1刘心娟1
作者信息
- 1. 100020,首都医科大学附属北京朝阳医院消化内科
- 折叠
摘要
Abstract
Objective To explore the potential association between the waist-to-arm ratio(WAR)and both metabolic dysfunc-tion-associated steatotic liver disease(MASLD)and hepatic fibrosis in older adults.Methods A total of 60-year-old and above elderly individuals from the National Health and Nutrition Examination Survey(NHANES)database from 2017 to 2020 were selected.WAR was used as the exposure variable and was categorized according to quartiles to assess its association with MASLD and hepatic fibrosis.Multivariable logistic regression model was used to estimate the relationship between WAR and the risk of MASLD and hepatic fibrosis,and subgroup analyses,interaction tests and restricted cubic spline analysis were performed to assess the non-linear association.Results A total of 2,084 participants were included in the study.The prevalence of MASLD was 42.7%,and that of hepatic fibrosis was 14.3%.WAR was divided into quartiles(Q1-Q4),each comprising 521 individuals.Multivariable logistic regression revealed a significant,positive association between higher WAR and the risk of MASLD(fully adjusted model OR=2.51;95%CI,1.69-3.72;P<0.001),and the risk of MASLD in the Q4 group was 1.12 times higher than that in the Q1 group(OR=2.12;95%CI,1.56-2.88;P<0.001).Similarly,an increase in WAR was also significantly positively associated with the risk of hepatic fibrosis(fully ad-justed model OR=2.35;95%CI,1.45-3.83;P=0.001),and the risk of hepatic fibrosis in the Q4 group was 1.11 times higher than that in the Q1 group(OR=2.11;95%CI,1.37-3.24;P=0.001).Subgroup analyses confirmed the consistency of these asso-ciations across all subgroups.Restricted cubic spline(RCS)regression indicated linear relationship between WAR and both MASLD and hepatic fibrosis(non-linearity P>0.05).Conclusions In older adults,WAR is significantly positively associated with the risk of MASLD and hepatic fibrosis.关键词
代谢功能障碍相关脂肪性肝病/肝纤维化/腰臂比值/健康与营养调查Key words
metabolic dysfunction-associated steatotic liver disease/waist-to-arm ratio/hepatic fibrosis/health and nutrition sur-vey分类
医药卫生引用本文复制引用
陈昭光,于剑锋,王燕斌,张冬磊,郝建宇,刘心娟..老年人腰臂比与代谢功能障碍相关脂肪性肝病及肝纤维化的相关性研究[J].武警医学,2026,37(6):477-483,7.
