现代妇产科进展2026，Vol.35Issue(6)：421-424,428,5.DOI:10.13283/j.cnki.xdfckjz.2026.06.004
新型男性外生殖器自取样器在HPV检测中的应用研究
Research on a novel male external genitalia self-sampling device in HPV detection
摘要
Abstract
Objective:To assess the feasibility of a novel all-round self-sampling device for exfoliated cells from the male external genitalia in HPV detection,offering a new strategy for male HPV screening.Methods:Male spouses of HPV-positive women attending the Department of Cervical Diseases,Weifang People's Hospital from September 2024 to November 2025 were enrolled.Each participant received both traditional clinician-collected sampling and the novel self-sampling.HPV genotyping and viral load were detected by real-time fluorescent PCR.A questionnaire evaluated participants'HPV knowledge and acceptance of the new device.Re-sults:Among 398 participants,the overall HPV infection rate was 59.8％(238/398).The HPV detection rate with self-sampling was 50.5％(201/398),significantly higher than with clinician-collected sampling(40.7％,162/398;P<0.001).Self-sampling also yielded a signif-icantly higher median viral load(P<0.01).The survey showed 89.2％preferred self-sam-pling,with high ratings for convenience(99.4％),comfort(78.7％reported no discomfort),and privacy protection.Conclusion:The novel self-sampling device outperforms traditional cli-nician-collected methods in HPV detection rate,viral load sensitivity,and user experience,pro-ving to be a reliable,efficient,and readily promotable tool for male HPV testing.关键词
人乳头瘤病毒/男性/自取样/病毒载量Key words
Human papillomavirus/Male/Self-sampling/Viral load分类
医药卫生引用本文复制引用
刘玉珍,牟文迪,宋温馨,王敏,刘露..新型男性外生殖器自取样器在HPV检测中的应用研究[J].现代妇产科进展,2026,35(6):421-424,428,5.基金项目
济南市"新高校20条"自主创新团队基金(No:2021GXRC027) （No:2021GXRC027）
山东省自然科学基金(No:ZR2023QH141) （No:ZR2023QH141）
