现代医药卫生2026，Vol.42Issue(6)：1265-1268,4.DOI:10.3969/j.issn.1009-5519.2026.06.013
芪苈强心胶囊对兔心力衰竭模型电重构影响的研究
Effect of Qiliqiangxin Capsule on electrical remodeling in a rabbit heart failure model
摘要
Abstract
Objective To investigate the effect of Qiliqiangxin Capsule on electrical remodeling in a rab-bit heart failure model using microelectrode array(MEA)technology.Methods Sixty New Zealand rabbits were randomly divided into 6 groups(n=10):control group,heart failure group,Qiliqiangxin A group(10 mg/kg),Qiliqiangxin B group(20 mg/kg),Qiliqiangxin C group(40 mg/kg),and Qiliqiangxin D group(80 mg/kg).After successful heart failure modeling,the hearts were rapidly excised and subjected to langendorff perfusion.Flexible electrodes were attached to the ventricular myocardium to record changes in field action po-tential duration(fAPD),conduction velocity(CV),and heart rate(HR)in each group.Results Compared with the control group,the fAPD in the ventricular myocardium of the heart failure group was significantly pro-longed,CV was slowed,and HR was significantly accelerated,with statistically significant differences(P<0.05).Compared with the heart failure group,fAPD of ventricular myocardium was shortened,CV was accel-erated,and HR was slowed in all Qiliqiangxin groups,the differences were all statistically significant(P<0.05),with the effect showing a concentration-dependent enhancement.Conclusion Qiliqiangxin Capsule can significantly improve electrical remodeling in a rabbit heart failure model.关键词
微电极阵/心力衰竭/电重构/芪苈强心胶囊/场电位时程/兴奋传导速度/心率Key words
Microelectrode array/Heart failure/Electrical remodeling/Qiliqiangxin Capsule/Field action potential duration/Conduction velocity/Heart rate分类
医药卫生引用本文复制引用
欧阳松,周国忠,侯月梅,李为洲..芪苈强心胶囊对兔心力衰竭模型电重构影响的研究[J].现代医药卫生,2026,42(6):1265-1268,4.基金项目
国家自然科学基金面上项目(81670308). （81670308）
