畜牧兽医学报2026，Vol.57Issue(6)：3138-3147,10.DOI:10.11843/j.issn.0366-6964.2026.06.014
纳米材料在动物骨关节炎治疗中的试验应用
Experimental Applications of Nanomaterials in Animal Osteoarthritis Treatment
摘要
Abstract
Osteoarthritis is a primary cause of pain and functional impairment in middle-aged and elderly animals.Osteoarthritis not only reduces animal productivity but also impacts quality of life and animal welfare,resulting in significant economic losses.Traditional drug therapies suffer from limitations such as poor drug targeting,short retention time,low bioavailability,and significant toxic side effects.In recent years,with the continuous advancement of nanomedicine delivery technology,intra-articular injection of nanomaterials has overcome the barriers and rapid clearance of conventional drugs within joints.This approach enables long-lasting,targeted,and highly efficient drug delivery,offering innovative strategies for osteoarthritis treatment.This paper comprehensively reviews and systematically summarizes experiment application progress on the use of nanomaterials in intra-articular injections for the treatment of osteoarthritis,focusing on potential mechanisms for targeted drug delivery and retention,promoting regenerative repair,and achieving anti-inflammatory and antioxidant effects.Exploring the application prospects of nanomedicine provides a theoretical foundation for innovative treatment strategies in animal osteoarthritis and future nanomaterial design and pharmacology research.关键词
纳米材料/纳米给药技术/关节腔内注射/骨关节炎/药物递送Key words
nanomaterials/nanoparticle drug delivery/intra-articular injection/osteoarthritis/drug delivery分类
农业科技引用本文复制引用
顾博,戚晶晶,张志恒,李淑欣,杨宝莲,白荟,张建涛,马天文..纳米材料在动物骨关节炎治疗中的试验应用[J].畜牧兽医学报,2026,57(6):3138-3147,10.基金项目
国家自然科学基金项目(32402967) （32402967）
中国博士后科学基金项目(2025MD774143) （2025MD774143）
新疆维吾尔自治区自然科学基金项目(2025D01A77) （2025D01A77）
