新中医2026，Vol.58Issue(12)：20-27,8.DOI:10.13457/j.cnki.jncm.2026.12.004
补阳还五汤治疗脑小血管病认知障碍临床研究
Clinical Study on Buyang Huanwu Tang in the Treatment of Cerebral Small Vessel Disease-Related Cognitive Impariment
摘要
Abstract
Objective:To observe the clinical effect of Buyang Huanwu Tang in the treatment of cerebral small vessel disease-related cognitive impairment.Methods:A total of 85 patients with cerebral small vessel disease-related cognitive impairment of qi deficiency and blood stasis type who were treated in the Department of Neurology,Binzhou Central Hospital from October 2022 to September 2024 were randomly divided into the control group(43 cases)and the Chinese medicine group(42 cases)using the random number table method.Patients in the control group were given conventional treatment;the Chinese medicine group was treated with Buyang Huanwu Tang Dispensing Granules based on the treatment plan of the control group.The cognitive function was evaluated by Mini-Mental State Examination(MMSE)and Montreal Cognitive Assessment(MoCA).The traditional Chinese medicine syndrome scores were calculated.The serum levels of hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6),and homocysteine(Hcy)were detected.The Fazekas visual rating scale was used to evaluate the load of white matter hyperintensity.The changes of the above indexes before and after treatment were analyzed and compared.Results:After treatment,the MMSE score and MoCA score in the Chinese medicine group were increased when compared with those before treatment,and each traditional Chinese medicine syndrome score and the Fazekas score were decreased when compared with those before treatment,differences being significant(P＜0.05).After treatment,the MMSE score and MoCA score in the Chinese medicine group were higher than those in the control group,and the symptom scores for dizziness and spontaneous sweating in the traditional Chinese medicine syndrome score were lower than those in the control group,differences being significant(P＜0.05);there was no significant difference being found in the comparison of Fazekas score between the Chinese medicine group and the control group(P＞0.05).After treatment,the levels of IL-6,hs-CRP,and Hcy in the two groups were decreased when compared with those before treatment,differences being significant(P＜0.05);the levels of IL-6 and hs-CRP in the Chinese medicine group were lower than those in the control group,differences being significant(P＜0.05);there was no significant difference being found in the comparison of Hcy level between the Chinese medicine group and the control group(P＞0.05).The incidence of adverse reactions was 13.95%(6/43)in the control group and 16.67%(7/42)in the Chinese medicine group,there being no significance in the difference(P＞0.05).Conclusion:In addition to the conventional treatment plan,Buyang Huanwu Tang in the treatment of cerebral small vessel disease-related cognitive impairment can reduce the traditional Chinese medicine syndrome scores,reduce the inflammatory factor levels,and help to improve the cognitive function of patients.关键词
脑小血管病/认知障碍/气虚血瘀证/补阳还五汤/简易智能精神状态检查量表/蒙特利尔认知评估量表/同型半胱氨酸/脑白质高信号Key words
Cerebral small vessel disease/Cognitive impairment/Qi deficiency and blood stasis syndrome/Buyang Huanwu Tang/MMSE/MoCA/Hcy/White matter hyperintensity分类
医药卫生引用本文复制引用
贾岩辉,崔真真,李浩,尤丽萍,张玉倩..补阳还五汤治疗脑小血管病认知障碍临床研究[J].新中医,2026,58(12):20-27,8.基金项目
山东省中医药科技项目(M-2022134) （M-2022134）
山东省医药卫生科技项目(202403071201) （202403071201）
