临床医学工程2026，Vol.33Issue(6)：672-676,5.DOI:10.3969/j.issn.1674-4659.2026.06.0672
左侧背外侧前额叶皮层与左侧外侧颞叶皮层重复经颅磁刺激治疗老年痴呆的效果分析
Analysis on the Effect of Repetitive Transcranial Magnetic Stimulation of the Left Dorsolateral Prefrontal Cortex and Left Lateral Temporal Cortex in the Treatment of Senile Dementia
摘要
Abstract
Objective To investigate the clinical efficacy of repetitive transcranial magnetic stimulation(rTMS)of the left dorsolateral prefrontal cortex and left lateral temporal cortex in the treatment of senile dementia,and to provide reference for clinical diagnosis and treatment.Methods A total of 60 patients with senile dementia admitted to Quzhou Third Hospital from September 2023 to September 2025 were enrolled as the research subjects.They were divided into the control group and the observation group by the random number table method,with 30 cases in each group.Both groups received basic treatment.On this basis,the control group received sham rTMS treatment,while the observation group received rTMS treatment of the left dorsolateral prefrontal cortex and left lateral temporal cortex.Both groups were treated continuously for 8 weeks.The cognitive function,event-related potentials,and activities of daily living were compared between the two groups.Reslults There were significant time effects,group effects,and interaction effects on the scores of Alzheimer's Disease Assessment Scale-Cognitive Subscale(ADAS-cog),Mini-Mental State Examination(MMSE),Addenbrooke's Cognitive Examination-Ⅲ(ACE-Ⅲ),Modified Barthel Index(MBI),as well as N,latency,P2 latency,and P3 amplitude between the two groups(all P＜0.05).After 4 and 8 weeks of treatment,the ADAS-cog scores of both groups showed a downward trend,and those in the observation group were significantly lower than those in the control group(P＜0.05);the MMSE,ACE-Ⅲ,and MBI scores of both groups showed an upward trend,and those in the observation group were significantly higher than those in the control group(P＜0.05).After 4 and 8 weeks of treatment,the N,latency and P2 latency of both groups showed a shortening trend,and those in the observation group were significantly shorter than those in the control group(P＜0.05);the P3 amplitude of both groups showed an increasing trend,and that in the observation group was significantly higher than that in the control group(P＜0.05).Conclusions rTMS of the left dorsolateral prefrontal cortex and left lateral temporal cortex is beneficial for improving cognitive function,event-related potentials,and activities of daily living in patients with senile dementia.关键词
老年痴呆/左侧背外侧前额叶皮层/左侧外侧颞叶皮层/重复经颅磁刺激Key words
Senile dementia/Left dorsolateral prefrontal cortex/Left lateral temporal cortex/Repetitive transcranial magnetic stimulation分类
医药卫生引用本文复制引用
江培杰..左侧背外侧前额叶皮层与左侧外侧颞叶皮层重复经颅磁刺激治疗老年痴呆的效果分析[J].临床医学工程,2026,33(6):672-676,5.基金项目
衢州市科技计划项目(项目编号:2020K142) （项目编号:2020K142）
