临床医学工程2026，Vol.33Issue(6)：743-746,4.DOI:10.3969/j.issn.1674-4659.2026.06.0743
MSCT增强征象联合血清VEGF-D、Cyfra21-1预测非小细胞肺癌纵隔淋巴结转移的价值研究
Study on the Value of Combined MSCT Enhanced Imaging Findings and Serum Levels of VEGF-D and Cyfra21-1 in Predicting Mediastinal Lymph Node Metastasis in Non-Small Cell Lung Cancer
摘要
Abstract
Objective To explore the predictive value of multi-slice spiral computed tomography(MSCT)enhancement features combined with serum vascular endothelial growth factor D(VEGF-D)and cytokeratin 19 fragment(Cyfra21-1)levels for mediastinal lymph node metastasis in non-small cell lung cancer(NSCLC).Methods Eighty NSCLC patients were divided into the metastatic group(n=32)and the non-metastatic group(n=48)based on surgical pathology results.All patients underwent MSCT enhancement scanning before surgery,and the short diameter,morphology,margin,enhancement pattern,and fusion of mediastinal lymph nodes were observed.Serum VEGF-D and Cyfra21-1 levels were also measured.Differences in MSCT enhancement features and serum marker levels between the two groups were compared,and Logistic regression was used to analyze risk factors for metastasis.The predictive performance of each indicator and combined detection was evaluated using ROC curves.Results In the metastatic group,lymph node short diameter ≥ 10 mm,irregular morphology,blurred margin,heterogeneous enhancement,fusion ratio,and serum VEGF-D and Cyfra21-1 levels were significantly higher than those in the non-metastatic group(P＜0.05).Multivariate Logistic regression analysis showed that lymph node short diameter ≥ 10 mm,irregular morphology,heterogeneous enhancement,and serum VEGF-D and Cyfra21-1 were independent risk factors for mediastinal lymph node metastasis in NSCLC(P＜0.05).ROC curve analysis revealed that the area under the curve(AUC)of combined detection was 0.932,with a sensitivity of 87.50％and a specificity of 91.67％,significantly higher than those of single indicator detection(P＜0.05).Conclusions The combination of MSCT enhancement features with serum VEGF-D and Cyfra21-1 detection can significantly improve the predictive accuracy of mediastinal lymph node metastasis in NSCLC,providing valuable reference for clinical treatment planning.关键词
非小细胞肺癌/纵隔淋巴结转移/多层螺旋CT/血管内皮生长因子D/细胞角蛋白19片段Key words
Non-small cell lung cancer/Mediastinal lymph node metastasis/Multi-slice spiral CT/Vascular endothelial growth factor D/Cyfra21-1分类
医药卫生引用本文复制引用
赵娜,崔萌萌..MSCT增强征象联合血清VEGF-D、Cyfra21-1预测非小细胞肺癌纵隔淋巴结转移的价值研究[J].临床医学工程,2026,33(6):743-746,4.基金项目
河南省医学科技攻关计划联合共建项目(项目编号:LHGJ20221010) （项目编号:LHGJ20221010）
