摘要
Abstract
Objective To investigate the efficacy of bronchoalveolar lavage combined with methylprednisolone sodium succinate in the treatment of severe Mycoplasma pneumoniae pneumonia in children.Methods A total of 103 children with severe Mycoplasma pneumoniae pneumonia admitted to the Department of Pediatrics of Puyang People's Hospital from September 2023 to April 2024 were selected and divided into an observation group(52 cases)and a control group(51 cases)using a random number table method.All enrolled children met the diagnostic criteria for severe Mycoplasma pneumoniae pneumonia and had clinical conditions under which bronchoscopic intervention could be considered;however,none had emergency indications requiring immediate bronchoalveolar lavage.All children received basic anti-infective treatment,including azithromycin,and symptomatic treatment.On this basis,the control group received methylprednisolone sodium succinate,while the observation group additionally received bronchoalveolar lavage.If children in the control group developed persistent airway obstruction,progression of atelectasis,worsening respiratory distress,or other conditions requiring bronchoscopic rescue,bronchoscopic intervention was performed according to clinical needs.The clinical efficacy,time to normalization of body temperature,time to disappearance of rales,time to improvement of cough,absorption of pulmonary lesions,and incidence of clinical adverse events were compared between the two groups.Results The overall response rate and pulmonary lesion absorption rate in the observation group were higher than those in the control group.The time to normalization of body temperature,time to disappearance of rales,and time to improvement of cough in the observation group were shorter than those in the control group,and all differences were statistically significant(P＜0.05).There was no statistically significant difference in the incidence of disease-related complications between the two groups(P＞0.05).Conclusion Bronchoalveolar lavage combined with methylprednisolone sodium succinate can improve short-term clinical symptoms and promote lesion absorption in children with severe Mycoplasma pneumoniae pneumonia,without a significant short-term increase in the incidence of complications.However,its long-term safety requires further investigation.关键词
重症肺炎支原体肺炎/儿童/支气管肺泡灌洗术/甲泼尼龙琥珀酸钠/临床疗效Key words
severe Mycoplasma pneumoniae pneumonia/children/bronchoalveolar lavage/methylprednisolone sodium succinate/clinical efficacy
