临床研究2026，Vol.34Issue(6)：73-76,4.DOI:10.12385/j.issn.2096-1278(2026)06-0073-04
围绝经期抑郁症患者血清E2、TSH、FT3、FT4水平与抑郁严重程度的关系
Relationship Between Serum E2,TSH,FT3,and FT4 Levels and Depression Severity in Patients with Perimenopausal Depression
摘要
Abstract
Objective To investigate the correlations of serum estradiol(E2),thyroid-stimulating hormone(TSH),free triiodothyronine(FT3),and free thyroxine(FT4)levels with depression severity and severe depression grouping in patients with perimenopausal depression.Methods A cross-sectional observational study was conducted.A total of 125 patients with perimenopausal depression who were consecutively admitted to Zhengzhou Eighth People's Hospital from October 2021 to October 2025 were selected as the study subjects.According to the severity of depression,the patients were divided into the mild-to-moderate depression group(n=93)and the severe depression group(n=32).General clinical data and serum E2,TSH,FT3,and FT4 levels at admission were compared between the two groups.The correlations between serum E2,TSH,FT3,and FT4 levels and Hamilton Depression Rating Scale(HAMD)scores were analyzed.Logistic regression analysis was used to evaluate the statistical associations between serum E2,TSH,FT3,and FT4 levels and severe depression grouping in patients with perimenopausal depression.Results The modified Kupperman score was higher and the disease duration was longer in the severe depression group than in the mild-to-moderate depression group,and the differences were statistically significant(P＜0.05).At admission,serum E2,TSH,FT3,and FT4 levels in the severe depression group were lower than those in the mild-to-moderate depression group,and the differences were statistically significant(P＜0.05).Serum E2,TSH,FT3,and FT4 levels were negatively correlated with HAMD scores(r=-0.704,-0.581,-0.637,and-0.519,respectively;P＜0.05).Logistic regression analysis showed that decreased serum E2,TSH,FT3,and FT4 levels were statistically associated with severe depression grouping in patients with perimenopausal depression(P＜0.05).Conclusion Decreased serum E2,TSH,FT3,and FT4 levels are correlated with increased HAMD scores and severe depression grouping in patients with perimenopausal depression,and these indicators may provide a certain reference for assessing depression severity.关键词
抑郁症/围绝经期/雌二醇/促甲状腺激素/游离三碘甲状腺原氨酸/游离甲状腺素Key words
depression/perimenopause/estradiol/thyroid-stimulating hormone/free triiodothyronine/free thyroxine引用本文复制引用
赵晨,吴君梅,孙玮..围绝经期抑郁症患者血清E2、TSH、FT3、FT4水平与抑郁严重程度的关系[J].临床研究,2026,34(6):73-76,4.基金项目
2024年度郑州市医疗卫生领域科技创新指导计划项目(2024YLZDJH347). （2024YLZDJH347）
