摘要
Abstract
Objective To investigate the effects of oxytocin and ergometrine maleate combined with tranexamic acid injection on blood loss,coagulation/fibrinolysis-related indicators,and uterine involution in women at high risk of postpartum hemorrhage undergoing cesarean section.Methods A total of 100 women who underwent cesarean section at Nanyang Oilfield General Hospital from November 2024 to March 2025 were selected and divided into a control group and an experimental group using a random number table method,with 50 women in each group.The control group received oxytocin injection combined with ergometrine maleate injection to prevent postpartum hemorrhage.The experimental group received intravenous infusion of tranexamic acid injection in addition to the treatment administered to the control group.Intraoperative blood loss,vaginal blood loss from after surgery to 24 h postpartum,laboratory indicators,uterine involution indicators,recovery indicators,and adverse reactions were compared between the two groups.Results Intraoperative blood loss and vaginal blood loss from after surgery to 24 h postpartum in the experimental group were lower than those in the control group.At 1 h and 24 h postpartum,hemoglobin and fibrinogen(FIB)levels in the experimental group were higher than those in the control group at the same time points,whereas thrombin time(TT),prothrombin time(PT),activated partial thromboplastin time(APTT),and D-dimer(D-D)levels were lower than those in the control group at the same time points(P＜0.05).The rate of postpartum uterine descent in the experimental group was greater than that in the control group,the length of hospital stay and time to initiation of lactation were shorter than those in the control group,and the cumulative duration of uterine contractions within 3 min postpartum was longer than that in the control group(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Adding tranexamic acid to oxytocin combined with ergometrine maleate may help reduce perioperative blood loss in women with high-risk factors for postpartum hemorrhage undergoing cesarean section,improve hemoglobin and some coagulation/fibrinolysis-related laboratory indicators,and promote early postpartum recovery,without increasing the incidence of adverse reactions within the observation scope of this study.关键词
剖宫产/产后出血/氨甲环酸/缩宫素/马来酸麦角新碱/凝血功能Key words
cesarean section/postpartum hemorrhage/tranexamic acid/oxytocin/methylergometrine maleate/coagulation function
