摘要
Abstract
Objective To investigate the efficacy of Tianmeng Oral Liquid combined with aripiprazole tablets in the treatment of schizophrenia of the spleen-kidney deficiency type.Methods A total of 100 patients with schizophrenia admitted to Shenqiu Psychiatric Hospital from August 2021 to December 2023 were selected and divided into an observation group(49 cases)and a control group(51 cases)using the random number table method.The control group was treated with oral aripiprazole tablets,while the observation group was additionally treated with Tianmeng Oral Liquid on the basis of the treatment given to the control group.The efficacy was evaluated after 2 months of continuous treatment in both groups.The Positive and Negative Syndrome Scale(PANSS)score,Montreal Cognitive Assessment(MoCA)score,Hamilton Anxiety Scale(HAMA)score,Hamilton Depression Scale(HAMD)score,activities of daily living(Barthel index),serum γ-aminobutyric acid(GABA),nerve growth factor(NGF),and brain-derived neurotrophic factor(BDNF)levels,and the incidence of adverse reactions were compared between the two groups.Results The treatment response rate in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).After treatment,the PANSS score,HAMA score,and HAMD score in the observation group were lower than those in the control group,while the Barthel index,MoCA score,and serum GABA,NGF,and BDNF levels were higher than those in the control group;the differences were statistically significant(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Tianmeng Oral Liquid combined with aripiprazole tablets in the treatment of schizophrenia of the spleen-kidney deficiency type may help relieve clinical symptoms,improve cognitive function and activities of daily living,and increase serum GABA,NGF,and BDNF levels,without significantly increasing adverse reactions within the observation scope of this study.关键词
精神分裂症/甜梦口服液/阿立哌唑片/认知功能/精神症状Key words
schizophrenia/Tianmeng Oral Liquid/aripiprazole tablets/cognitive function/psychiatric symptoms
