中草药2026，Vol.57Issue(13)：4964-4968,5.DOI:10.7501/j.issn.0253-2670.2026.13.002
香附中2个新的二苯醚类化合物
Two new diphenyl ethers from Cyperus rotundus
摘要
Abstract
Objective To investigate the chemical constituents and their antitumor activities isolated from Cyperus rotundus.Methods The isolates were isolated and purified by silica gel,Sephadex gel,reversed-phase C18 column chromatography,and semi-preparative high-performance liquid chromatography(HPLC).The structures of the obtained compounds were elucidated by spectroscopic methods such as nuclear magnetic resonance(NMR)and mass spectrometry(MS).Finally,all compounds were subjected to MTT assays to evaluate their anti-tumor activities.Results Two new diphenyl ethers were obtained from C.rotundus,specifically as 2,3'-dihydroxy-5,2',5'-trimethoxy diphenyl ether(1)and 2,3'-dihydroxy-4,2',5'-trimethoxy diphenyl ether(2).Both compounds exhibited moderate inhibitory effects on human colon cancer cell line HCT116,with median inhibition concentration(IC50)values of(24.20±0.77)and(25.26±0.65)μmol/L,respectively.Conclusion Compounds 1 and 2 are new compounds with anti-tumor potential,named cydipethers A(1)and B(2).Diphenyl ethers were identified from C.rotundus for the first time.关键词
莎草科/香附/二苯醚/抗肿瘤/香附二苯醚A/香附二苯醚BKey words
Cyperaceae/Cyperus rotundus L./diphenyl ether/antitumor/cydipethers A/cydipethers B分类
医药卫生引用本文复制引用
胡雅丽,刘青云,汪汝渊..香附中2个新的二苯醚类化合物[J].中草药,2026,57(13):4964-4968,5.基金项目
云南省教育厅科学研究基金项目-青年人才基础研究专项(2025J0009) （2025J0009）
云南大学医学科研基金-青年项目(YDYXJJ2024-0050) （YDYXJJ2024-0050）
