中草药2026，Vol.57Issue(13)：5273-5286,14.DOI:10.7501/j.issn.0253-2670.2026.13.028
荧光探针在中药材二氧化硫残留分析中的应用与进展
Application and research progress of fluorescent probes in detection of sulfur dioxide residues in traditional Chinese medicinal materials
摘要
Abstract
The safety of traditional Chinese medicines(TCMs)is of paramount importance.Sulfur fumigation,a traditional processing and preservation technique for TCMs,serves to prevent mold during storage and improve product appearance.However,excessive sulfur fumigation leads to sulfur dioxide(SO2)residues in the herbs,posing potential health risks.Currently,the SO2 residue detection methods suffer from limitations including long analysis time,high cost,and operational complexity,making them inadequate for meeting the market demand for rapid testing.Fluorescent probe technology,with its advantages of high sensitivity,portability,simple preparation,and rapid response,has been widely applied in pharmaceutical development,biotechnology,and food safety.In recent years,the use of highly selective and sensitive fluorescent probes for the quantitative or semi-quantitative detection of SO2 residues in TCMs has emerged as a significant research focus.This review systematically summarizes fluorescent probes developed in recent years for detecting SO2 residues in TCMs,categorizing them based on their recognition mechanisms or structural features.It focuses on application progress of these probes in practical detection scenarios,analyzes the current technical challenges,and discusses future development directions.This review aims to provide theoretical foundations and technical references for enhancing the medicinal safety and quality control of TCMs.关键词
荧光探针/二氧化硫残留量/中药/定量分析/快速检测Key words
fluorescent probes/sulfur dioxide residues/traditional Chinese medicine/quantitative analysis/rapid detection分类
医药卫生引用本文复制引用
邢成,张明童,靳婉君,张生杰,姚立琼,乌丹..荧光探针在中药材二氧化硫残留分析中的应用与进展[J].中草药,2026,57(13):5273-5286,14.基金项目
国家重点研发计划中医药现代化专项(2023YFC3504103) （2023YFC3504103）
甘肃省卫生健康行业科研项目(GSWSKY2024-45) （GSWSKY2024-45）
甘肃省兰州大学大学生省级创新创业训练计划项目(20240060176) （20240060176）
兰州大学第一医院院内基金(ldyyyn2025-281) （ldyyyn2025-281）
