中风与神经疾病杂志2026，Vol.43Issue(6)：510-513,4.DOI:10.19845/j.cnki.zfysjjbzz.2026.0088
烟雾综合征患者脑血流低灌注对认知功能的影响
Influence of cerebral hypoperfusion on cognitive function in moyamoya syndrome
摘要
Abstract
Objective To investigate the clinical and radiological features of patients with moyamoya syndrome(MMS)and the influence of cerebral hypoperfusion on cognitive function in MMS.Methods A total of 153 patients with MMS who were consecutively admitted to Henan Provincial People's Hospital from June 2023 to December 2024 were enrolled,and according to the presence or absence of cognitive impairment,they were divided into cognitive impair-ment group with 73 patients and normal cognitive function group with 80 patients.The two groups were compared in terms of clinical data,cranial MRI data,and perfusion-weighted magnetic resonance imaging(PWI-MRI)data,and the Logistic regression analysis was used to investigate the influencing factors for cognitive impairment in MMS patients.Results Based on the results of Montreal Cognitive Assessment(MoCA)and Mini-Mental State Examination(MMSE),the incidence rate of cognitive impairment in MMS patients was 47.71%(73/153).PWI-MRI showed that in the cognitive impairment group,the patients with local cerebral hypoperfusion(a reduction in relative blood volume)ac-counted for 49.32%(36/73),while in the normal cognitive function,the patients with local hypoperfusion accounted for 31.25%(25/80),and there was a significant difference between the two groups(χ2=5.196,P<0.05).Frontal hypo-perfusion(OR=2.098,95%CI 1.049‒4.196,P=0.036)was a risk factor for cognitive impairment in MMS patients.Conclusion Cognitive impairment is common in MMS patients,and MMS patients with frontal hypoperfusion are more likely to develop cognitive impairment.关键词
烟雾综合征/认知障碍/灌注加权磁共振成像/脑血流低灌注Key words
Moyamoya syndrome/Cognitive impairment/Perfusion-weighted imaging/Cerebral hypoperfusion分类
医药卫生引用本文复制引用
张秀雅,高言梅,师晶晶,聂肖肖,赵建华..烟雾综合征患者脑血流低灌注对认知功能的影响[J].中风与神经疾病杂志,2026,43(6):510-513,4.基金项目
河南省医学科技攻关计划项目(SBGJ202102034) （SBGJ202102034）
河南省科技计划重点项目(22210231077) （22210231077）
