中国病理生理杂志2026，Vol.42Issue(6)：1214-1220,7.DOI:10.3969/j.issn.1000-4718.2026.06.017
CD34+细胞在心血管疾病中作用机制及治疗应用的研究进展
Progress in mechanisms and therapeutic applications of CD34+cells in cardiovascular diseases
摘要
Abstract
Cardiovascular diseases represent a significant threat to human health globally.With in-depth re-search in stem cells and regenerative medicine,the application of bone marrow transplantation and cell therapy in cardio-vascular diseases is becoming increasingly widespread.Among these,CD34+cells have emerged as critical therapeutic agents due to their multipotent differentiation capabilities.These cells contribute to cardiac remodeling,vascular regenera-tion,and the mitigation of ischemia and fibrosis associated with cardiovascular pathologies through diverse mechanisms,suggesting their potential clinical relevance across a range of cardiovascular disorders.Nonetheless,clinical trial out-comes have been inconsistent,with some studies reporting adverse effects such as aberrant inflammatory responses and pathological endothelial proliferation following CD34+cell therapy,thereby generating considerable debate regarding their therapeutic efficacy.The advent of single-cell RNA sequencing technology has revealed that CD34+cells constitute a het-erogeneous population,comprising tissue-resident and hematopoietic subsets.Depending on specific microenvironmental cues or induction conditions,CD34+cells can differentiate into various cell types,including endothelial cells,inflammato-ry cells,and fibroblasts,each fulfilling distinct functional roles.Therefore,in this review,we will summarize the origins and functions of CD34+cells and explore their differentiation and functional mechanisms in peripheral vascular diseases,aortic vascular diseases,and various cardiac diseases.关键词
CD34/骨髓移植/细胞治疗/外周血管疾病/心肌梗死/心力衰竭Key words
CD34/bone marrow transplant/cell therapy/peripheral vascular disease/myocardial infarction/heart failure分类
医药卫生引用本文复制引用
蒋漫玲,任奕璇,杨知韵,林子皓,谭晓秋,陈唐葶..CD34+细胞在心血管疾病中作用机制及治疗应用的研究进展[J].中国病理生理杂志,2026,42(6):1214-1220,7.基金项目
国家自然科学基金资助项目(No.82470323) （No.82470323）
四川省科技厅重点项目(No.2025ZNSFSC0052) （No.2025ZNSFSC0052）
泸州市科技局自然科学基金项目(No.2023JYJ004) （No.2023JYJ004）
