中国病理生理杂志2026，Vol.42Issue(6)：1227-1234,8.DOI:10.3969/j.issn.1000-4718.2026.06.019
白血病中氧化还原稳态调控机制及靶向治疗策略的研究进展
Advances in regulatory mechanisms and targeted therapeutic strategies of redox homeostasis in leukemia
摘要
Abstract
The dynamic equilibrium between oxidative stress and antioxidant systems serves as a pivotal regu-latory mechanism in leukemogenesis,disease progression,and therapeutic responses.At low concentrations,reactive oxy-gen species(ROS)promote proliferation and immune evasion of leukemia cell through activating signaling pathways such as phosphatidylinositol 3-kinase(PI3K)/protein kinase B(PKB/Akt)and nuclear factor-κB(NF-κB).Different leukemia subtypes have unique redox characteristics with significant differences in ROS levels and antioxidant system activity.Leu-kemia cells have evolved robust antioxidant defense systems through the nuclear factor E2-related factor 2(Nrf2)-Kelch-like ECH-associated protein 1(Keap1)pathway,glutathione metabolic network,and metabolic reprogramming,thus en-abling them to maintain aberrant redox homeostasis and develop drug-resistance.In recent years,therapeutic strategies tar-geting redox homeostasis have demonstrated significant potential,and combination therapy strategies have shown synergis-tic effects.However,their clinical translation is still limited by leukemia heterogeneity,insufficient dynamic monitoring technologies,and off-target toxicity.This review has systematically summarized the regulatory mechanism of oxidative stress and antioxidant systems in leukemia and explores their potential clinical applications.关键词
白血病/活性氧/氧化还原稳态/耐药性/靶向治疗Key words
leukemia/reactive oxygen species/redox homeostasis/drug resistance/targeted therapy分类
医药卫生引用本文复制引用
游若兰,方文琪,黄慧芳..白血病中氧化还原稳态调控机制及靶向治疗策略的研究进展[J].中国病理生理杂志,2026,42(6):1227-1234,8.基金项目
福建省科技创新联合项目(No.2023Y9122) （No.2023Y9122）
福建省政府资助高水平实验室建设项目[(闽)201704号] （闽）
