中国防痨杂志2026，Vol.48Issue(7)：1038-1043,6.DOI:10.19982/j.issn.1000-6621.20260160
832例老年肺结核患者共病谱及核心中医证候的关联研究
An association study of the comorbidity spectrum and core traditional Chinese medicine syndromes in 832 elderly patients with pulmonary tuberculosis
摘要
Abstract
Objective:To characterize the comorbidity spectrum of elderly patients with pulmonary tuberculosis,explore its association with core traditional Chinese medicine(TCM)syndromes,and analyze differences across age and gender strata,so as to provide evidence for syndrome-disease integrated individualized management.Methods:A retrospective analysis was conducted.A total of 832 elderly patients with pulmonary tuberculosis hospitalized at Lishui Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University from January 2022 to October 2024 were enrolled.Demographic data,TCM syndromes,and comorbidities were collected via electronic medical records.The distribution of comorbidities and their associations with two core syndromes-qi-yin deficiency syndrome and yin-yang deficiency syndrome-were analyzed.Stratified analyses were performed by age(60-69 years,70-79 years,≥80 years)and gender.Results:Among the 832 patients,the overall comorbidity prevalence was 64.66％(538/832).The top three comorbidities were hypertension(32.57％(271/832)),respiratory diseases(29.57％(246/832)),and diabetes mellitus(25.00％(208/832)).Patients with ≥3 comorbidities accounted for 21.75％(181/832).The core TCM syndromes were qi-yin deficiency syndrome(39.30％(327/832))and yin-yang deficiency syndrome(25.36％(211/832)).Compared with patients with yin-yang deficiency syndrome,those with qi-yin deficiency syndrome had higher rates of diabetes mellitus(44.65％(146/327)vs.28.44％(60/211);OR=2.030,95％CI:1.400-2.944)and respiratory diseases(44.65％(146/327)vs.26.54％(56/211);OR=2.230,95％CI:1.532-3.247).In contrast,they had lower rates of chronic kidney disease(3.67％(12/327)vs.22.27％(47/211);OR=0.133,95％CI:0.069-0.257),malignancy(6.73％(22/327)vs.17.06％(36/211);OR=0.351,95％CI:0.199-0.619),and multimorbidity(≥3 conditions)(25.69％(84/327)vs.34.12％(72/211);OR=0.667,95％CI:0.460-0.968).Conclusion:Elderly patients with pulmonary tuberculosis carry a heavy comorbidity burden.Core TCM syndromes are distinctly associated with specific comorbidities,suggesting that stratified and individualized interventions should be implemented based on syndrome-disease interactions.关键词
结核,肺/老年人/共病现象/中医证候/统计学分布Key words
Tuberculosis,pulmonary/Aged/Comorbidity/Traditional Chinese medicine syndrome/Statistical distributions分类
医药卫生引用本文复制引用
丰银平,罗水荣,刘忠达,张尊敬..832例老年肺结核患者共病谱及核心中医证候的关联研究[J].中国防痨杂志,2026,48(7):1038-1043,6.基金项目
国家中医药管理局科技司-浙江省中医药管理局共建科技计划项目(GZY-ZJ-KJ-23096) （GZY-ZJ-KJ-23096）
浙江省老年肺结核诊治中医药多学科交叉创新团队 Science and Technology Program Co-constructed by the Department of Science and Technology of the National Administration of Traditional Chinese Medicine and the Zhejiang Administration of Traditional Chinese Medicine(GZY-ZJ-KJ-23096) （GZY-ZJ-KJ-23096）
Zhejiang Provincial Multidisciplinary Innovation Team of Traditional Chinese Medicine for the Diagnosis and Treatment of Elderly Pulmonary Tuberculosis （）
