中国防痨杂志2026，Vol.48Issue(7)：1044-1050,7.DOI:10.19982/j.issn.1000-6621.20250480
中和汤辅助治疗气血两虚证脓肿型淋巴结结核的随机对照研究短期疗效观察
Adjuvant therapy with Zhonghe Decoction for abscess lymph node tuberculosis with Qi and blood deficiency syndrome:a randomized controlled trial on short-term efficacy
摘要
Abstract
Objective:To evaluate the short-term efficacy of Zhonghe Decoction as an adjuvant therapy for abscess lymph node tuberculosis with Qi and blood deficiency syndrome.Methods:A prospective randomized controlled design was adopted.A total of 80 patients with non-drug-resistant cervical abscess lymph node tuberculosis(Qi and blood deficiency syndrome)admitted to Beijing Chest Hospital,Capital Medical University from January 2022 to December 2024 were enrolled and randomly divided into an observation group and a control group,with 40 cases in each group.After 7 dropouts,36 cases were finally included in the observation group and 37 cases in the control group.Both groups received the H-R-Z-E(Isoniazid,Rifampicin,Pyrazinamide,Ethambutol)anti-tuberculosis regimen for one year.The observation group was additionally treated with Zhonghe Decoction for 6 months.Abscess size,Traditional Chinese Medicine(TCM)syndrome score,quality of life score,and adverse reactions were evaluated in both groups before treatment,at 6 weeks,and at 24 weeks of treatment.Results:At 6 weeks of treatment,the abscess improvement rate in the observation group was 77.78％(28/36),significantly higher than that in the control group(32.43％,12/37)(x2=15.150,P＜0.05);the total effective rate for TCM syndrome efficacy was 88.89％(32/36)in the observation group,also superior to that in the control group(27.03％,10/37)(x2=28.590,P＜0.05).At 24 weeks of treatment,the favorable outcome rate in the observation group was 72.22％(26/36),significantly higher than that in the control group(27.03％,10/37)(x2=14.920,P＜0.05).Regarding quality of life,,after 6 weeks of treatment,the median(interquartile range)score for physical functioning in the observation group was 3.98(—0.42,8.38),while that in the control group was 0.34(—4.86,5.53),with a statistically significant difference(Z=226.290,P＜0.05).The score for role-physical in the observation group was 59.93(20.36,99.50),compared to 33.24(—26.76,93.23)in the control group,showing a statistically significant difference(Z=212.203,P＜0.05).The score for bodily pain in the observation group was 24.50(—4.75,53.75),while that in the control group was 12.50(—4.12,24.50),with a statistically significant difference(Z=224.837,P＜0.05).No serious adverse events occurred in two groups.Conclusion:Zhonghe Decoction can promote the absorption of abscesses in lymph node tuberculosis,accelerate symptom relief,and improve patients' quality of life,demonstrating definite efficacy and good safety.关键词
结核,淋巴结/药物,中草药/随机对照试验Key words
Tuberculosis,lymph node/Drugs,Chinese herbal/Randomized controlled trial分类
医药卫生引用本文复制引用
赵丽萍,梁博文,曹艳华,李波,罗敬月,王桂荣,黄麦玲,宗星煜,曹玉清,姜慧,蔡秋杰,马艳,穆婷婷,刘晓明,刘斌..中和汤辅助治疗气血两虚证脓肿型淋巴结结核的随机对照研究短期疗效观察[J].中国防痨杂志,2026,48(7):1044-1050,7.基金项目
首都卫生发展科研专项(2022-4-2164) （2022-4-2164）
北京研究型病房卓越计划(BRWEP2024W042160104) Capital's Funds for Health Improvement and Research(2022-4-2164) （BRWEP2024W042160104）
Beijing Research Ward Excellence Program(BRWEP2024W042160104) （BRWEP2024W042160104）
