中国康复理论与实践2026，Vol.32Issue(6)：631-644,14.DOI:10.3969/j.issn.1006-9771.2026.06.002
间歇性θ脉冲刺激改善脑卒中患者下肢运动和平衡功能的Meta分析
Effect of intermittent theta burst stimulation on lower extremity motor function and balance function in stroke patients:a meta-analysis
摘要
Abstract
Objective To systematically evaluate the effect of intermittent theta burst stimulation(iTBS)on lower extremity motor function and balance function in patients with stroke. Methods A systematic literature search was conducted in the Cochrane Library,Embase,PubMed,Web of Science,CNKI,SinoMed,Wanfang data and VIP from inception to February 19,2025.Randomized controlled trials com-paring iTBS with conventional rehabilitation or sham iTBS in patients with post-stroke lower extremity motor and balance dysfunction were included.The methodological quality of the included studies was assessed using the Cochrane Risk of Bias Tool.Meta-analysis was performed using RevMan 5.4 and Stata 14.0. Results A total of 16 articles involving 647 patients were included.Meta-analysis showed that iTBS improved the Fugl-Meyer Assessment-Lower Extremities score(MD=2.58,95％CI 1.61 to 3.55,P<0.001),Berg Balance Scale score(MD=4.11,95％CI 2.43 to 5.79,P<0.001),Barthel Index score(MD=4.95,95％CI 0.97 to 8.92,P=0.010)and motor-evoked potential(MEP)latency(MD=-1.42,95％CI-2.54 to-0.30,P=0.010).Subgroup analyses suggested that at subacute stage,cerebellar iTBS,more than ten treatment sessions,and 1 200 pulses per day may be more effective. Conclusion iTBS may improve lower extremity motor function and activities of daily living in patients with stroke,and shorten MEP latency,and it may also confer potential benefits in improving balance function in these patients.关键词
脑卒中/间歇性θ脉冲刺激/下肢/运动功能/平衡/康复/Meta分析Key words
stroke/intermittent theta burst stimulation/lower extremity/motor function/balance/rehabilitation/meta-analysis分类
医药卫生引用本文复制引用
李欣源,郑洁皎,张廷宇,吴雪娇,梁晓笑..间歇性θ脉冲刺激改善脑卒中患者下肢运动和平衡功能的Meta分析[J].中国康复理论与实践,2026,32(6):631-644,14.基金项目
上海市科委"科技创新行动计划"医学创新研究专项重大疑难疾病诊疗方案(策略)临床研究(No.22Y31900200)Supported by Shanghai Science and Technology Commission Science and Technology Innovation Action Plan Clinical Research on Diagnosis and Treatment Plan(Strategy)for Major Difficult Diseases(No.22Y31900200) （策略）
