摘要
Abstract
Background Metabolic associated fatty liver disease(MAFLD)and hypertension are prevalent chronic conditions in older adults,with accumulating evidence linking both to metabolic dysfunction.The cardiometabolic index(CMI)is a composite parameter that evaluates visceral adipose distribution and metabolic status,yet its association with incident hypertension among elderly MAFLD patients remains to be elucidated.Objective To investigate the association of CMI with incident hypertension in elderly patients with MAFLD,and to evaluate the predictive value of CMI for hypertension development in this population.Methods Elderly non-hypertensive patients diagnosed with MAFLD during health check-ups at Yingzhong and Zijin Community Health Centers affiliated with Changzhi People's Hospital between January and December 2021 were enrolled.Follow-up investigations were conducted from January 2022 to December 2024,and 426 elderly MAFLD patients who completed follow-up were ultimately included in this study.Baseline characteristics and relevant clinical data were collected,and CMI was calculated.Participants were stratified into three tertile groups based on CMI:T1(CMI<0.467,n=141),T2(0.467≤CMI<0.758,n=142),and T3(CMI≥0.758,n=143).They were further categorized into non-hypertension(n=355)and hypertension(n=71)groups based on incident hypertension during follow-up.Kaplan-Meier survival analysis was performed to estimate the cumulative incidence of hypertension across CMI groups,with between-group differences assessed using the Log-rank test.Multivariate Cox proportional hazards regression and restricted cubic spline(RCS)analysis were used to evaluate the association between CMI and incident hypertension.Sex-stratified analysis and sensitivity analysis were performed to examine the robustness of this association.Furthermore,time-dependent receiver operating characteristic(ROC)curves were constructed to assess the predictive performance of CMI for hypertension development in elderly MAFLD patients.Results During a median follow-up period of 36.00(27.75,38.00)months,71 patients(16.7%)developed incident hypertension.There were statistically significant differences between the non-hypertension and hypertension groups in age,waist circumference,BMI,CMI,TC,TG,LDL-C,and HDL-C(P<0.05).Log-rank test demonstrated that the cumulative incidence of hypertension increased significantly across T1 to T3 groups with elevated CMI levels(χ2=26.468,P<0.001).Multivariate Cox proportional hazards regression analysis revealed that when analyzed as a continuous variable,CMI was significantly and positively associated with incident hypertension in elderly MAFLD patients after adjusting for relevant confounders(HR=1.927,95%CI=1.381-2.689,P<0.001).When CMI was analyzed as a categorical variable with the T1 group as the reference,the risk of developing hypertension was significantly higher in the T3 group after adjusting for confounders(HR=5.453,95%CI=2.268-13.109,P<0.001).Interaction analysis showed no statistically significant interaction between CMI and gender(Pinteraction=0.557).Sensitivity analysis demonstrated that the association between CMI and hypertension remained significant after excluding participants with MAFLD remission.RCS analysis showed a non-linear dose-response relationship between CMI and the risk of hypertension in elderly MAFLD patients(Pnon-linearity=0.005).The risk of hypertension exhibited a continuous upward trend with increasing CMI levels,which plateaued when CMI exceeded 1.185.Time-dependent ROC curve analysis showed that CMI demonstrated optimal predictive performance for hypertension at 24 months of follow-up,with an AUC of 0.722(95%CI=0.618-0.827).Over time,the AUC decreased to 0.648(95%CI=0.537-0.759)and 0.652(95%CI=0.542-0.763)at 30 and 36 months,respectively.Conclusion CMI is significantly positively associated with incident hypertension in elderly MAFLD patients,and its measurement can be used to assess the short-term(24-month)risk of hypertension development in this population.关键词
高血压/代谢相关脂肪性肝病/老年人/心脏代谢指数/预测/队列研究/前瞻性队列研究Key words
Hypertension/Metabolic associated fatty liver disease/The elderly/Cardiometabolic index/Prediction/Cohort study/Prospective cohort study分类
医药卫生
