中国比较医学杂志2026，Vol.36Issue(9)：55-62,8.DOI:10.3969/j.issn.1671-7856.2026.09.005
血脂康通过AMPK/eNOS对糖尿病肾病大鼠的肾脏保护作用
Reno protective effect of Xuezhikang in diabetic kidney disease rats via AMPK/eNOS
摘要
Abstract
Objective To investigate the renoprotective effect of Xuezhikang in rats with diabetic kidney disease(DKD),via AMP-activated protein kinase(AMPK)/endothelial nitric oxide synthase(eNOS)pathway.Methods SD rats were divided randomly into five groups:control,DKD model,Xuezhikang(DKD modeling+1 200 mg/(kg·d)Xuezhikang by gavage),inhibitor group(DKD modeling+0.2 mg/(kg·d)AMPK inhibitor Compound C by intraperitoneal injection),and Xuezhikang+inhibitor(DKD modeling+1 200 mg/(kg·d)Xuezhikang by gavage+0.2 mg/(kg·d)AMPK inhibitor Compound C by intraperitoneal injection).Renal pathological changes,renal function indicators(24-hour urine albumin,serum creatinine(Scr),blood urea nitrogen(BUN)),expression levels of phosphorylated AMPK(p-AMPK)and eNOS,and levels of inflammatory indicators(tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)),oxidative stress indicators(superoxide dismutase(SOD)and malondialdehyde(MDA))in the kidneys were detected after 4 weeks of the respective interventions.Results Compared with the model group,renal pathological changes were alleviated,levels of 24-hour urinary albumin,Scr,BUN,TNF-α,IL-6,and MDA in the kidneys decreased,while expression levels of p-AMPK,eNOS,and SOD increased in the Xuezhikang group(P＜0.05).In addition,renal pathological changes were aggravated,levels of 24-hour urinary albumin,Scr,BUN,TNF-α,IL-6,and MDA in the kidneys increased,while expression levels of p-AMPK,eNOS,and SOD decreased in the inhibitor group(P＜0.05).Compared with the Xuezhikang group,renal pathological changes were aggravated,levels of 24-hour urinary albumin,Scr,BUN,TNF-α,IL-6,and MDA in the kidneys increased,while expression levels of p-AMPK,eNOS,and SOD decreased in the Xuezhikang+inhibitor group(P＜0.05).Conclusions Xuezhikang alleviates renal injury and the inflammatory and oxidative stress responses in DKD rats by activating AMPK/eNOS.关键词
糖尿病肾病/血脂康/腺苷酸蛋白活化激酶/内皮型一氧化氮合酶Key words
diabetic kidney disease/Xuezhikang/adenosine 5'-monophosphate-activated protein kinase/endothelial nitric oxide synthase分类
医药卫生引用本文复制引用
韩小丽,赵琦,董娟,赵锦纹,蒋秀峰,卫志锋,刘翠兰..血脂康通过AMPK/eNOS对糖尿病肾病大鼠的肾脏保护作用[J].中国比较医学杂志,2026,36(9):55-62,8.基金项目
张家口市科学技术局2024年市级科技计划(2421067D). （2421067D）
