中国比较医学杂志2026，Vol.36Issue(9)：75-87,13.DOI:10.3969/j.issn.1671-7856.2026.09.007
基于层次分析法-熵权法的低等级生物安全实验室风险评估体系的构建
Combining AHP and Entropy weight method to develop a risk assessment system for low-level biosafety laboratories
摘要
Abstract
Objective The rapid development of biotechnology has highlighted the importance of biosafety in the field of public health;however,the large number and wide distribution of low-level biosafety laboratories present potential risks that urgently need effective identification,control,and prevention.Methods This study targeted frontline biosafety laboratory personnel from hospitals,community diagnostic centers,and health-administration departments.Two rounds of anonymous expert consultations were conducted using the Delphi method,followed by a combination of an analytic hierarchy process and entropy weight method for integrated weighting,ultimately forming a risk assessment indicator system for low-level biosafety laboratories combining subjective and objective evaluations.Results Thirty experts participated in the first round and 35 in the second.Two rounds of anonymous consultation and feedback revisions produced a systematic risk-assessment indicator system,including five primary indicators(A1～A5:personnel risk prevention and control,equipment safety management,sample risk management,laboratory system construction,laboratory environmental management),10 secondary indicators(B1-1～B5-1),and 30 tertiary indicators(C1-1-1～C5-1-3).The Kendall harmony coefficient was 0.23(P＜0.001),and the consistency ratios of the judgment matrices at all levels were less than 0.1,indicating good coordination of expert opinions and reasonable weight allocation.Conclusions A unified risk-assessment indicator system for low-level biosafety laboratories was constructed based on dimensions such as personnel,equipment,samples,regulations,and environment,with quantified indicator weights.This enriches research on standardized assessments in this field.The system is applicable to daily risk management of low-level biosafety laboratories,supervision and inspection by regulatory authorities,and related academic research.关键词
生物安全/风险评估/德尔菲法/生物安全实验室Key words
biosafety/risk assessment/Delphi method/biosafety laboratory分类
医药卫生引用本文复制引用
刘稹诚,热伊莱·麦麦提,卢耀勤,王亮,马秀敏,丁蕾,俞婧,夏梦杰,周燚然,杨清月,李宝军..基于层次分析法-熵权法的低等级生物安全实验室风险评估体系的构建[J].中国比较医学杂志,2026,36(9):75-87,13.基金项目
新疆维吾尔自治区科技创新团队(天山创新团队)(2022TSYCTD0015). （天山创新团队）
