中国比较医学杂志2026，Vol.36Issue(9)：106-120,15.DOI:10.3969/j.issn.1671-7856.2026.09.009
阿尔茨海默病中内质网应激-自噬溶酶体轴的作用及中医药调控机制
Role of endoplasmic reticulum stress-autophagy-lysosome axis in Alzheimer's disease and the regulatory mechanism of traditional Chinese medicine
摘要
Abstract
Protein homeostasis imbalance has recently been shown to play a significant role in the pathogenesis of Alzheimer's disease.Endoplasmic reticulum stress and autophagy-lysosomal pathway dysfunction serve as key regulatory nodes,forming a tightly functional interactive network via a bidirectional feedback mechanism referred to as the endoplasmic reticulum stress-autophagic lysosomal axis.Interventions using traditional Chinese medicine can regulate the interaction of this axis,alleviate neuronal damage and death,and thereby improve cognitive function impairment.Various single components of traditional Chinese medicine(e.g.,dihydroartemisinin,oleanolic acid,curcumin,ligustilide,and baicalin)can coordinate the balance between endoplasmic reticulum stress and autophagy-lysosomal pathways by regulating key factors such as GRP78,CHOP,LC3,LAMP1,and p62.In addition,traditional Chinese medicine combinations(e.g.,Huanglian Jiedu Decoction,Kai-xin-san,Dihuang Yinzi,Jiajian Shuyu Pill,and Heixiaoyao Power)exert neuroprotective effects by alleviating endoplasmic reticulum stress and correcting autophagolysosomal functional defects through pathways such as PINK1-Parkin,ATF4-CHOP,IRE1-XBP1,and mTOR.This review systematically considers the interaction between endoplasmic reticulum stress and the autophagic lysosomal axis in the pathogenesis of Alzheimer's disease,and the regulatory mechanisms of traditional Chinese medicine,with the aim of providing new ideas for the prevention and treatment of Alzheimer's disease and the modernization of research into traditional Chinese medicine.关键词
阿尔茨海默病/内质网应激/自噬溶酶体/中医药Key words
Alzheimer's disease/endoplasmic reticulum stress/autophagolysosome/traditional Chinese medicine分类
医药卫生引用本文复制引用
常茜茜,刘冰心,吕怡琳,刘源,褚长松,马慧芬,宋军营..阿尔茨海默病中内质网应激-自噬溶酶体轴的作用及中医药调控机制[J].中国比较医学杂志,2026,36(9):106-120,15.基金项目
河南省自然科学基金(252300423162) （252300423162）
河南省高校科技创新人才项目(25HASTIT062). （25HASTIT062）
