中国比较医学杂志2026，Vol.36Issue(9)：121-130,10.DOI:10.3969/j.issn.1671-7856.2026.09.010
成对关联刺激治疗脑卒中后运动功能障碍的研究进展
Research progress on paired associative stimulation for post-stroke motor dysfunction
摘要
Abstract
Paired associative stimulation(PAS)is a novel non-invasive brain stimulation technique based on spike-timing-dependent plasticity(STDP),which modulates neuroplasticity by combining transcranial magnetic stimulation with peripheral nerve electrical stimulation,effectively improving post-stroke motor dysfunction.Its mechanism involves STDP-induced long-term potentiation-or depression-like changes,mediated by brain-derived neurotrophic factor-dependent synaptic remodeling,while selectively regulating the interhemispheric inhibitory balance to promote functional reorganization.PAS has recently emerged as a research hotspot in the field of neurorehabilitation for post-stroke motor dysfunction,demonstrating broad prospects for clinical applications.This review summarizes the mechanisms and clinical applications of PAS for treating post-stroke motor dysfunction.Future research should focus on validating the long-term efficacy and developing individualized treatment protocols to advance the clinical translation of PAS.关键词
成对关联刺激/经颅磁刺激/脑卒中/运动功能障碍/脉冲时序依赖可塑性/半球间抑制Key words
paired associative stimulation/transcranial magnetic stimulation/stroke/motor dysfunction/spike-timing-dependent plasticity/interhemispheric inhibition分类
医药卫生引用本文复制引用
张航耀,白艳杰,栗文静,刘安,王岩,刘瑞芳,朱利静,王雪,李雪晨..成对关联刺激治疗脑卒中后运动功能障碍的研究进展[J].中国比较医学杂志,2026,36(9):121-130,10.基金项目
2022年度河南省卫健委国家中医临床研究基地科研专项(2022JDZX005) （2022JDZX005）
2025年度河南省高等学校重点科研项目(25A360018) （25A360018）
河南省中医药传承与创新人才工程(仲景工程)中医药拔尖人才(CZ0237-08) （仲景工程）
河南省中医药拔尖人才专项课题(2022ZYBJ07). （2022ZYBJ07）
