中国比较医学杂志2026，Vol.36Issue(9)：131-142,12.DOI:10.3969/j.issn.1671-7856.2026.09.011
基于"虚气留滞"理论探讨线粒体自噬对缺血性脑卒中的调控机制
Exploring the regulatory mechanism of mitophagy on ischemic stroke based on the theory of"Qi Deficiency and Stasis"
摘要
Abstract
Ischemic stroke(IS)is a common cerebrovascular disease with a complex pathogenesis and a prolonged,refractory clinical course.Under the guidance of the traditional Chinese medicine theory of"Qi Deficiency and Stasis,"IS can be characterized as a syndrome of deficiency in origin and excess in manifestation,with"Qi Deficiency"as the root and"Stasis"as the manifestation.Recent research has demonstrated the extensive involvement of mitophagy,as a key process in maintaining cellular homeostasis,in the regulation of IS.Its functional state aligns with the pathological changes described in the"Qi Deficiency and Stasis"theory.This review systematically explores the intrinsic relationship between the"Qi Deficiency and Stasis"theory and mitophagy in the occurrence and progression of IS,while proposing therapeutic strategies.By establishing a bridge between traditional Chinese medicine pathogenesis and modern biological mechanisms,it provides a new theoretical basis and research direction for targeting mitophagy in the prevention and treatment of IS based on the"Qi Deficiency and Stasis"theory.关键词
虚气留滞/缺血性脑卒中/线粒体自噬/中医药Key words
Qi Deficiency and Stasis/ischemic stroke/mitophagy/traditional Chinese medicine分类
医药卫生引用本文复制引用
杭雪莹,郝颖煦,刘向哲..基于"虚气留滞"理论探讨线粒体自噬对缺血性脑卒中的调控机制[J].中国比较医学杂志,2026,36(9):131-142,12.基金项目
国家重点研发计划资助项目(2022YFC3501103) （2022YFC3501103）
河南省科技攻关项目(242102311277) （242102311277）
河南省"双一流"创建学科中医学科研专项课题(HSRP-DFCTCM-2023-2-18) （HSRP-DFCTCM-2023-2-18）
河南省中医药传承与创新人才工程(仲景工程)中医药学科领军人才(豫卫中医函[2021]8号) （仲景工程）
河南省卫健委国家中医药传承创新中心联合共建科研重大专项(2024ZXZX1017). （2024ZXZX1017）
