中国比较医学杂志2026，Vol.36Issue(11)：88-101,14.DOI:10.3969/j.issn.1671-7856.2026.11.010
组蛋白甲基化修饰在阿尔茨海默病中的作用及其中药干预研究进展
Research progress on histone methylation regulation by traditional Chinese medicine for Alzheimer's disease prevention and treatment
摘要
Abstract
Alzheimer's disease(AD)is a progressive neurodegenerative disorder characterized by memory loss,cognitive impairment,language dysfunction,and loss of behavioral abilities in its later stages.Because of its complex pathogenesis,there are currently no effective treatments available.Abnormal epigenetic modifications are closely associated with AD onset and progression of AD.Histone methylation is an important epigenetic modification that participates in AD pathology by dynamically regulating chromatin structure and gene transcription;it plays an important regulatory role in Aβ plaque formation,tau hyperphosphorylation,neuroinflammation,synaptic plasticity,and neuronal death.Traditional Chinese medicine has unique advantages for AD prevention and treatment;its active ingredients can regulate histone methylation to improve AD,mainly through reducing the production of A β and highly phosphorylated tau to alleviate neuroinflammatory responses,repair synaptic plasticity damage,and increase neuronal survival.This paper reviews the key role of histone methylation in AD and current research on traditional Chinese medicine interventions,providing a theoretical basis for the clinical treatment of AD and the research,development,and application of traditional Chinese medicine.关键词
组蛋白甲基化/AD/中药/认知功能Key words
histone methylation/AD/traditional Chinese medicine/cognitive function分类
医药卫生引用本文复制引用
肖冰玉,马金莲,李中华,孙天成,张振强..组蛋白甲基化修饰在阿尔茨海默病中的作用及其中药干预研究进展[J].中国比较医学杂志,2026,36(11):88-101,14.基金项目
国家自然科学基金(82274612) （82274612）
河南省科技攻关项目(242102311249) （242102311249）
河南省博士后科研项目启动金(HN2022100). （HN2022100）
