中国比较医学杂志2026，Vol.36Issue(11)：102-109,8.DOI:10.3969/j.issn.1671-7856.2026.11.011
NETosis在ARDS中的作用机制及组蛋白修饰对其的调控作用
Research progress on the regulation of NETosis by histone modifications in sepsis-associated acute respiratory distress syndrome
摘要
Abstract
Acute respiratory distress syndrome(ARDS)is a common critical disease in clinical practice.Neutrophil extracellular traps(NETs)play a dual role in its pathogenesis,acting as an important immune defense mechanism and a key factor leading to lung tissue damage.Neutrophil extracellular traps formation(NETosis)is precisely regulated by histone modification.This review systematically explores the specific molecular mechanisms by which key modifications such as histone citrullination,acetylation,and methylation regulate NETosis in ARDS.The cross-dialogue among different modifications and their interactions in the ARDS inflammatory network is explored,and the translational prospects and challenges of targeting histone modifier-NETosis pathways represented by PAD4 inhibitors for ARDS treatment are explored,aiming to provide new ideas and a theoretical basis for future research.关键词
ARDS/组蛋白修饰/NETosisKey words
ARDS/histone modification/NETosis分类
医药卫生引用本文复制引用
王媛媛,郑晓文..NETosis在ARDS中的作用机制及组蛋白修饰对其的调控作用[J].中国比较医学杂志,2026,36(11):102-109,8.基金项目
国家自然科学基金(82460376). （82460376）
