中国比较医学杂志2026，Vol.36Issue(11)：110-121,12.DOI:10.3969/j.issn.1671-7856.2026.011.012
中医药调控PI3K/Akt通路改善卵巢储备功能减退的研究进展
Research progress on the mechanism of traditional Chinese medicine in improving diminished ovarian reserve function by regulating the PI3K/Akt signaling pathway
摘要
Abstract
Diminished ovarian reserve(DOR)is a common gynecological condition.The incidence of DOR is increasing in line with the trend of delayed marriage and childbirth,showing a younger age of onset and seriously affecting female fertility and quality of life.Current Western medical treatments for DOR mainly rely on hormone replacement and assisted reproductive technologies,but these are associated with significant side effects and unreliable efficacy.Traditional Chinese medicine(TCM)offers advantages in terms of multi-target and multi-pathway regulation,effectively modulating hormone levels,promoting follicular development,and delaying ovarian aging with high safety,making it an important complementary clinical approach.The phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt)signaling pathway is a core regulator of ovarian granulosa cell proliferation,apoptosis,autophagy,and oxidative stress,and its dysregulation is closely linked to the pathogenesis and progression of DOR.This article reviews the mechanisms of the PI3K/Akt pathway in DOR,including apoptosis,the inflammatory response,autophagy,and oxidative stress,and summarizes recent research progress on the role of TCM monomers(such as kaempferol and curcumin)and compound formulas(such as Yulin Formula and Yulin Hukun Decoction)in improving DOR by regulating this pathway,providing a theoretical basis for precise TCM interventions in DOR.关键词
卵巢储备功能减退/PI3K/Akt信号通路/中医药Key words
diminished ovarian reserve/PI3K/Akt signaling pathway/traditional Chinese medicine分类
医药卫生引用本文复制引用
丁文佳,黄淑萍,李良颖,谢彩英,张依婷,李卫红..中医药调控PI3K/Akt通路改善卵巢储备功能减退的研究进展[J].中国比较医学杂志,2026,36(11):110-121,12.基金项目
全国名中医陈慧侬学术思想与临床诊疗传承发展推广中心建设项目(桂中医大党委[2022]23号). （桂中医大党委[2022]23号）
