中国比较医学杂志2026，Vol.36Issue(11)：122-130,9.DOI:10.3969/j.issn.1671-7856.2026.11.013
急性应激诱导焦虑模型的价值探微
Exploring the value of acute stress-induced anxiety models
摘要
Abstract
Anxiety disorder is a common mental disorder in clinical practice that imposes a heavy burden on families and society.Commonly used anti-anxiety drugs have slow onsets,significant side effects,and slow drug development processes.The core bottleneck lies in the lack of animal models that can accurately simulate the characteristics of human anxiety disorders.Acute stress is a key factor that triggers anxiety disorders and can restore the initial stage of anxiety disorder onset.Acute stress animal models provide a key carrier for exploring the pathogenesis of anxiety disorders and screening anti-anxiety drugs.This article systematically elaborates on the concept and clinical significance of acute stress,the preparation of animal models of anxiety caused by acute stress,techniques for testing model effectiveness,potential biological mechanisms,and the application directions and future prospects in this field.This review aims to provide theoretical references and an experimental basis for research and clinical translation for understanding and treating anxiety disorders.关键词
焦虑/急性应激/动物模型/生物学机制Key words
anxiety/acute stress/animal models/biological mechanism分类
医药卫生引用本文复制引用
李由,董洪玮,吴浩然,纪亭如,杨轹文,张浩..急性应激诱导焦虑模型的价值探微[J].中国比较医学杂志,2026,36(11):122-130,9.基金项目
国家自然科学基金(82305065,82204958) （82305065,82204958）
山东省自然科学基金(ZR2023QH078,ZR2025MS1225) （ZR2023QH078,ZR2025MS1225）
中国博士后科学基金(2025T181085) （2025T181085）
山东省高等学校"青创团队计划"团队(2024KJJ061,2023KJ191). （2024KJJ061,2023KJ191）
