中国实用内科杂志2026，Vol.46Issue(6)：441-446,6.DOI:10.19538/j.nk2026060101
轻中度慢性阻塞性肺疾病患者早期干预的人群选择策略
Population selection strategy for early intervention in patients with mild to moderate chronic obstructive pulmonary disease
摘要
Abstract
Chronic obstructive pulmonary disease(COPD)is a major global public health issue.Patients with mild to moderate COPD account for more than 90％of the total COPD population,and managing this group is expected to significantly reduce the overall disease burden.Early use of drugs such as tiotropium can improve lung function,slow the decline in lung function,reduce acute exacerbations,and lower the risk of clinically important deterioration.However,not all patients with mild to moderate COPD require pharmacological intervention.Due to the significant heterogeneity in mild to moderate COPD,which includes different phenotypes,endotypes,and disease progression patterns,there is an urgent need for multidimensional assessment of progression risks for COPD,as well as precise pharmacological treatment for mild to moderate COPD with rapid progression.This approach could delay disease progression and reduce disease burden,while also avoiding overtreatment.关键词
慢性阻塞性肺疾病/早期干预/人群选择Key words
chronic obstructive pulmonary disease/early intervention/population selection分类
医药卫生引用本文复制引用
王梓晖,吴繁,周玉民,冉丕鑫,钟南山..轻中度慢性阻塞性肺疾病患者早期干预的人群选择策略[J].中国实用内科杂志,2026,46(6):441-446,6.基金项目
国家自然科学基金面上项目(82570065) （82570065）
广州国家实验室项目(SRPG22-016,SRPG22-018) （SRPG22-016,SRPG22-018）
