中国实用内科杂志2026，Vol.46Issue(6)：462-468,7.DOI:10.19538/j.nk2026060104
慢性阻塞性肺疾病患者运动诱发低氧饱和度与呼吸康复中的氧疗策略
Strategies for oxygen therapy in pulmonary rehabilitation:managing exercise-induced desaturation in patients with chronic obstructive pulmonary disease
摘要
Abstract
The prevalence of exercise-induced desaturation(EID)ranges from 5％to 62％due to varied definitions,and is significantly associated with accelerated lung function decline,a 50％increased risk of acute exacerbation,and elevated all-cause mortality.As a core respiratory rehabilitation intervention for EID in patients with chronic obstructive pulmonary disease(COPD),oxygen therapy can synergize with exercise training(e.g.,intermittent aerobic plus resistance training)to overcome EID-related limitations.Titrated oxygen therapy significantly improves exercise endurance during a single test session and enhances muscle adaptability compared to fixed-flow oxygen therapy.High-flow nasal cannula(HFNC)prolongs constant work-rate exercise time.In terms of safety,titrated oxygen therapy does not exacerbate carbon dioxide(CO2)retention in patients with hypercapnia.Future efforts should focus on identifying the populations most likely to gain benefit(e.g.,based on EID severity),optimizing closed-loop feedback technologies,and deeply integrating oxygen therapy with multidisciplinary rehabilitation programs to enhance functional independence in patients.关键词
运动诱发低氧饱和度/滴定式氧疗/肌肉适应性/经鼻高流量吸氧/闭环供氧系统Key words
exercise-induced desaturation/titrated oxygen therapy/muscle adaptation/high-flow nasal cannula/closed-loop oxygen supply system分类
医药卫生引用本文复制引用
曲木诗玮,杨汀..慢性阻塞性肺疾病患者运动诱发低氧饱和度与呼吸康复中的氧疗策略[J].中国实用内科杂志,2026,46(6):462-468,7.基金项目
中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-049) （2021-I2M-1-049）
国家自然科学基金青年项目(82200051) （82200051）
